Turner And Klinefelter Treatment Target study

Recruiting

• Conditions: Turner and Klinefelter syndrome

• Registration Number: NL-OMON22530
• Lead Sponsor: one

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 350

Inclusion Criteria

Klinefelter or Turner syndrome as confirmed by genetic testing - Sufficient knowledge of the Dutch language to complete the questionnaires - At least 18 years old

Exclusion Criteria

- KS: Patients not under treatment in the EMC or VUmc or no planned visits during the study period - TS: No laboratory values or no questionnaires available in patient records - Severe psychiatric or neurologic disorders or other reasons for inability to complete the questionnaires as assessed by the treating physician. - Failure to obtain informed consent

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The relationship between thyroid hormone status and QoL as measured by the EQ-5D-5L in patients with TS. The relationship between testosterone and QoL as measured by the EQ-5D-5L in patients with KS.

Secondary Outcome Measures

Name	Time	Method
For TS: The relationship between thyroid hormone status* and the CIS-20, PSS scores and hair cortisol levels. The relationship between liver enzymes** and the EQ-5D-5L, CIS-20, PSS scores and hair cortisol levels. <br> <br>For KS: The relationship between testosterone and the CIS-20, LSAS, PSS scores and hair cortisol levels<br><br>*Variable that consists of the following 6 categories: - Overt hyperthyroidism (FT4>25pmol/L and TSH<0,4mU/L) - Overt hypothyroidism (FT4 <11 pmol/L and TSH >4,3 mU/L) - Subclinical hypothyroidism met TSH <10mU/L (FT4 11-25 pmol/L and TSH 4,3-10mU/L) - Subclinical hypothyroidismmet TSH >10mU/L (FT4 11-25 pmol/L and TSH > 10mU/L) - Subclinical hyperthyroidism (FT4 11-25 pmol/L and TSH <0,4 mU/L) - Euthyroidism (FT4 11-25 pmol/L and TSH 0,4- 4,3 mU/L) <br> <br>** aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT), bilirubin, lactate dehydrogenase (LDH)