Robotic Versus Laparoscopic Liver Resection for Hepatocellular Carcinoma

Completed

• Conditions: Hepatocellular Carcinoma
• Interventions: Procedure: Minimally invasive liver resection

• Registration Number: NCT06496113
• Lead Sponsor: Ente Ospedaliero Cantonale, Bellinzona

Brief Summary

The objective of the study is to investigate the long-term outcomes of minimally invasive liver surgery (robotic vs laparoscopic) for hepatocellular carcinoma patients of stage BCLC 0-A. Data from two tertiary centers for liver surgery will be retrospectively reviewed. Patients will be divided in two cohorts (robot; laparoscopy). The primary endpoint will be recurrence-free and overall survival; secondary endpoints were incidence, pattern, and treatment of recurrences.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-01
• Primary Completion: 2024-04
• Study Completion: 2024-06
• Status Verified: 2024-07
• Study First Submitted: 2024-07-01
• Study First Submitted QC: 2024-07-08
• Last Update Submitted: 2024-07-08
• Study First Posted: 2024-07-11
• Last Update Posted: 2024-07-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 196

Inclusion Criteria

• Patients undergoing robotic and laparoscopic resections
• Histology-confirmed HCC of stage BCLC 0-A
• Preserved liver function (Child score A-B)
• Patients >18 years old

Exclusion Criteria

• Hand-assisted procedures
• Non-elective surgery
• Intraoperative switch to locoregional therapies (like radiofrequency or microwave ablation)
• Non-histologically confirmed HCC
• Mixed hepato-cholangiocarcinoma.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Robotic liver resections	Minimally invasive liver resection	-
Laparoscopic liver resection	Minimally invasive liver resection	-

Primary Outcome Measures

Name	Time	Method
Overall survival	From the date of liver resection until the date of death for any cause or the last follow-up available whichever came first, assessed up to 116 months. The Minimum follow-up accepted was of 3 months postoperatively.
Recurrence-free survival	From the date of liver resection until the first documented HCC progression on follow-up imaging, assessed up to 116 months. The Minimum follow-up accepted was of 3 months postoperatively.	Recurrence was dated at the first HCC detection on follow-up imaging.