Randomized study of tamoxifen versus goserelin acetate vs combination as preoperative endocrine therapy for estrogen receptor positive pre-menopausal patients.
Phase 2
- Conditions
- Estrogen receptor positive, pre-menopausal breast cancer
- Registration Number
- JPRN-UMIN000006286
- Lead Sponsor
- Yokohama City University Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- Female
- Target Recruitment
- 220
Inclusion Criteria
Not provided
Exclusion Criteria
1) hypersensitivity to test drug 2) serious complication (malignant hypertention, congestive heart failure, coronary failure, cardiac infarction in last 6 month, arhythmia which need treatment, infection disease, bleeding tendency, etc.) 3) Patients who administrate anticlotting drug or SSRI 4)Patinent who have double cancer 5)Ductal carcinoma in situ or inflamatory breast cancer 6) Bilateral breast cancer, male breast cancer 7) Pregnant women, breat-feeding mother, possibility of pregnancy 8) History of thrombosis 9) History of mental disease or under medical treatment. 10)Patient regarded as inadequate by responsible doctor
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Suppression of Ki-67
- Secondary Outcome Measures
Name Time Method Safety Response rate Histopathological response Predictive factor Relapse-free survival