Deoxyribonucleic acid (DNA) and Sperm DNA Fragmentation Investigation in Patients Undergoing In vitro fertilisation (IVF)/Intracytoplasmic sperm injection (ICSI) with History of Recurrent Implantation Failure and/or Recurrent Pregnancy Loss

Not Applicable

Completed

• Conditions: patients with recurrent IVF failure and/or implantation failure; Reproductive Health and Childbirth - Fertility including in vitro fertilisation

• Registration Number: ACTRN12614000188639
• Lead Sponsor: Gamze Sinem Caglar

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-02-21
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

*18-45 years old
*IVF/ICSI indication due to primary or secondary infertility
*History of failure to achieve a clinical pregnancy after transfer of at least four good-quality embryos in a minimum of three fresh or frozen cycles in a woman under the age of 40years
*History of 2 or more pregnancy losses before 20th week of gestation
*non smokers
*subjects with female partner of less than 35 years old
*not having documented sexually transmitted disease
*not having a history of genital tract operation

Exclusion Criteria

*smokers
*documented azoospermia
*female partner older than age 35
*documented poor ovarian reserve or high ovarian response in females
*documented sexually transmitted disease for both participants
*history of genital tract surgery in male participant

Study & Design

• Study Type: Observational
• Study Design: Not specified