The effect of 8 weeks of combined exercise training (aerobic-resistance) on microRNAs involved in pain, inflammation and fatigue in patients with MS.
Not Applicable
- Conditions
- multiple sclerosis.Multiple sclerosis
- Registration Number
- IRCT20230618058515N1
- Lead Sponsor
- Research Institute of Neuroscience, Faculty of Medical Sciences, Tehran
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 36
Inclusion Criteria
Male and female patients with MS with EDSS 1 to 4
Only patients using interferon-beta medication alone will participate in the study.
Age range from 25 to 45 years
Lack of regular physical activity in the last 6 months
Ability to perform sports protocol
Exclusion Criteria
Worsening of the patient's condition
Inability to complete the exercise protocol
The beginning of the relapse period
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method MiR-155 , miR-326, miR-23b, miR-146a. Timepoint: Before starting the training program and 24 hours after the last training session. Method of measurement: RT-PCR.
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms link combined aerobic-resistance exercise to microRNA regulation in multiple sclerosis?
How does combined exercise training compare to standard MS therapies in modulating pain and inflammation biomarkers?
Which microRNAs serve as biomarkers for MS patient response to aerobic-resistance exercise interventions?
What adverse events are associated with combined aerobic-resistance training in MS populations?
Are there synergistic effects between exercise-induced microRNA changes and MS disease-modifying therapies?