Prophylactic effect of N-acetyl-cysteine plus Atorvastatin versus N-acetyl-cysteine and Atorvastatin alone for the prevention of contrast induced nephropathy
Phase 3
Recruiting
- Conditions
- Contrast induced nephropathy.Other complications following infusion, transfusion and therapeutic injectionT80.8
- Registration Number
- IRCT20180417039347N1
- Lead Sponsor
- Zahedan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 250
Inclusion Criteria
Eligible patients include individuals older than 21 years old
abnormal renal function (Creatinine clearance between 15 and 60 mL/min or serum creatinine (SCr) =1.1 mg/dL)
Undergoing elective cardiac catheterization with or without PCI
Exclusion Criteria
Patients with end-stage renal failure (glomerular filtration rate (GFR) = 15 mL/min),
history of previous dialysis
pulmonary edema
emergency cardiac catheterization (patients with ST-segment elevation myocardial infarction undergoing primary PCI ),
exposure to contrast within previous two days ago before procedure
allergies to contrast media,
contraindication to statins
liver disease
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum creatinine level altration. Timepoint: Serum creatinine levels are measured on the first day (day before the procedure) and 48 hours after exposure. Method of measurement: creatinine test.
- Secondary Outcome Measures
Name Time Method Incidence of CIN. Timepoint: 48 h post exposure contrast media. Method of measurement: creatinine test.