Effect of Atrovastatin on lung inflammation in bronchitis
Phase 3
- Conditions
- Chronic bronchitis.Chronic bronchitis: obstructive
- Registration Number
- IRCT138904144312N1
- Lead Sponsor
- shiraz University Of medical Science
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Male
- Target Recruitment
- 90
Inclusion Criteria
exposure to mustard gas during the Iran-Iraq war and have suffered from chronic bronchitis (history of chronic cough and sputum daily for 3 months during recent 2 years)
Exclusion criteria: Using statin in the last 3 months of study starting time; exacerbation of symptoms in the past 4 weeks; connective tissue disease; sarcoidosis; eosinophilic granuloma; pneumoconiosis; lymphoma; carcinomatous; smokers
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method TNF alpha level. Timepoint: before intervention - 3 month after intervention. Method of measurement: ELISA test is performed.;Interleukin 6 level. Timepoint: before intervention - 3 month after intervention. Method of measurement: ELISA test is performed.;Added at 2015-08-05: Procalcitonin. Timepoint: Added at 2015-08-05: At the beginning of the intervention and 3 months after intervention. Method of measurement: Added at 2015-08-05: ELISA.
- Secondary Outcome Measures
Name Time Method Withe blood cell count. Timepoint: before intervention - 3 month after intervention. Method of measurement: Complete Blood Count.;Added at 2015-08-05: hs-CRP. Timepoint: Added at 2015-08-05: At the beginning the intervention and 3 months after intervention. Method of measurement: Added at 2015-08-05: Immunoassay.