Redistribution of pulmonary blood flow as a cause for the progression of pulmonary hypertensionin after chronic thrombo-emboli.

Completed

• Conditions: Chronic thromboembolic pulmonary hypertension AND increased pressure in pulmonary vessels due to bloodclots; 10019280; 10014523

• Registration Number: NL-OMON31465
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

- Mean pulmonary artery pressure (mPAP) > 25 mmHg.
- Specific features of chronic thromboembolism on pulmonary angiography as
assessed by radiologist(s).
- No previous treatment of oral anticoagulation

Exclusion Criteria

- Presence of systemic inflammation.
- Patients with pulmonary hypertension associated with collagen vascular disease, congenital heart disease, pulmonary venous hypertension, left heart failure, hypoxemic lung disease (COPD)
- bad kidney function (creatinin > 120)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p> Changes assessed by MRI between obstructed and non-obstructed regions<br /><br>of the lungs by means of:<br /><br>- Pulmonary blood volume<br /><br>- Pulmonary blood flow<br /><br>- Mean transit time<br /><br>- Pulmonary vascular resistance</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>