A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)
- Conditions
- Non-Small Cell Lung Cancer (NSCLC)
- Interventions
- Registration Number
- NCT05920356
- Lead Sponsor
- Amgen
- Brief Summary
The primary objective of this study is to compare progression-free survival (PFS) in participants who receive sotorasib with platinum doublet chemotherapy versus participants who receive pembrolizumab with platinum doublet chemotherapy.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 750
- Histologically or cytologically confirmed diagnosis of nonsquamous stage IV or advanced Stage IIIB or IIIC NSCLC with KRAS p. G12C mutation and negative for PD-L1 expression by central testing or local laboratory testing confirmed through central testing
- No history of systemic anticancer therapy in metastatic/non-curable settings
- Eastern Cooperative Oncology Group (ECOG) ≤ 1
- Mixed histology NSCLC with either small-cell or large-cell neuroendocrine cell component or predominant squamous cell histology
- Participants with tumors known to harbor molecular alterations for which targeted therapy is locally approved
- Symptomatic (treated or untreated) brain metastases
- Gastrointestinal (GI) tract disease causing the inability to take oral medication
- Myocardial infarction within 6 months of randomization, unstable arrhythmias, or unstable angina
- Prior therapy with a KRAS G12C inhibitor
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Sotorasib combined with carboplatin and pemetrexed Sotorasib Sotorasib administered in combination with carboplatin and pemetrexed. Pembrolizumab combined with carboplatin and pemetrexed Pembrolizumab Pembrolizumab administered in combination with carboplatin and pemetrexed.
- Primary Outcome Measures
Name Time Method Progression-free Survival (PFS) From Baseline up to end of study (EOS) (approximately 5.5 years) PFS is defined as the time from randomization until the first documentation of radiologic disease progression or death due to any cause, whichever occurs first. Progression will be based on Response Evaluation Criteria in Solid Tumors (RECIST) v1.1, per Blinded Independent Central Review (BICR).
- Secondary Outcome Measures
Name Time Method Objective Response Rate (ORR) From Baseline up to EOS (approximately 5.5 years) Objective response is defined as the best overall response of complete response (CR) or partial response (PR), based on RECIST v1.1, per BICR.
Overall Survival (OS) From Baseline up to EOS (approximately 5.5 years) OS is defined as the time from randomization until death due to any cause.
Change in Quality-of-Life Questionnaire Core 30 (QLQ-C30) Dyspnea Domain Score From Baseline to Week 12 Change in Quality-of-Life Questionnaire Lung Cancer 13 (QLQ-LC13) Symptoms of Dyspnea Subscale From Baseline to Week 12 Change in QLQ-LC13 Symptoms of Cough Subscale From Baseline to Week 12 Change in QLQ-LC13 Symptoms of Chest Pain Subscale From Baseline to Week 12 Change in Physical Function as Measured by QLQ-C30 From Baseline to Week 12 Change in Global Health Status as Measured by QLQ-C30 From Baseline to Week 12 Progression-free Survival 2 (PFS2) From Baseline up to EOS (approximately 5.5 years) PFS2 is defined as the time from randomization to progression per investigator after initiation of new anticancer therapy or treatment beyond progression (ie, second progression) or death from any cause, whichever occurs first.
Change in QLQ-LC13 Subscale Scores From Baseline up to EOS (approximately 5.5 years) Change in QLQ-C30 Subscale Scores From Baseline up to EOS (approximately 5.5 years) Time to Deterioration in QLC-LC13 Subscale Scores From Baseline to Week 12 Time to Deterioration in QLC-C30 Subscale Scores From Baseline to Week 12 Change in Summary Scores and Visual Analogue Scale (VAS) Scores From Baseline up to EOS (approximately 5.5 years) Measured by EuroQol-5 Dimension (EQ-5D-5L).
Duration of Response From Baseline up to EOS (approximately 5.5 years) Duration of response is defined as the time from the first documentation of objective response until the first documentation of disease progression per BICR or death due to any cause, whichever occurs first.
Time to Response From Baseline up to EOS (approximately 5.5 years) Defined as the time from randomization to first evidence of PR or CR per BICR.
Disease Control From Baseline up to EOS (approximately 5.5 years) Defined as CR plus PR plus stable disease based on RECIST v1.1 per BICR.
PFS From Baseline up to EOS (approximately 5.5 years) Based on investigator tumor assessments per RECIST v1.1.
Objective Response From Baseline up to EOS (approximately 5.5 years) Based on investigator tumor assessments per RECIST v1.1.
Number of Participants With Treatment-Emergent Adverse Events From Baseline up to EOS (approximately 5.5 years) Number of Participants With Clinically Significant Changes in Vital Signs From Baseline up to EOS (approximately 5.5 years) Number of Participants With Clinically Significant Changes in Clinical Laboratory Tests From Baseline up to EOS (approximately 5.5 years) Maximum Plasma Concentration (Cmax) of Sotorasib Pre-dose Day 1 up to Day 64 Minimum Plasma Concentration (Cmin) of Sotorasib Pre-dose Day 1 up to Day 64 Area Under The Curve (AUC) of Sotorasib Pre-dose Day 1 up to Day 64
Trial Locations
- Locations (359)
Sansum Clinic
🇺🇸Santa Barbara, California, United States
University of Illinois Chicago
🇺🇸Chicago, Illinois, United States
Illinois Cancer Specialists
🇺🇸Niles, Illinois, United States
Norton Cancer Institute - Brownsboro
🇺🇸Louisville, Kentucky, United States
Reliant Medical Group Inc
🇺🇸Worcester, Massachusetts, United States
University of New Mexico Cancer Center
🇺🇸Albuquerque, New Mexico, United States
Memorial Sloan Kettering Cancer Center
🇺🇸New York, New York, United States
Duke University
🇺🇸Durham, North Carolina, United States
FirstHealth Cancer Center
🇺🇸Pinehurst, North Carolina, United States
Alliance Cancer Specialists - Media
🇺🇸Media, Pennsylvania, United States
University of Pittsburgh Medical Center
🇺🇸Pittsburgh, Pennsylvania, United States
University of Tennessee Medical Center Knoxville
🇺🇸Knoxville, Tennessee, United States
Sarah Cannon Research Institute
🇺🇸Nashville, Tennessee, United States
United States Oncology Regulatory Affairs Corporate Office
🇺🇸Nashville, Tennessee, United States
University of Texas MD Anderson Cancer Center
🇺🇸Houston, Texas, United States
US Oncology Research Investigational Products Center
🇺🇸Irving, Texas, United States
Hospital Britanico de Buenos Aires
🇦🇷Caba, Buenos Aires, Argentina
Instituto Alexander Fleming
🇦🇷Capital Federal, Buenos Aires, Argentina
Instituto Argentino de Diagnostico y Tratamiento IADT
🇦🇷Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Hospital Italiano de La Plata
🇦🇷La Plata, Buenos Aires, Argentina
Fundacion Ars Medica
🇦🇷San Salvador de Jujuy, Jujuy, Argentina
Clinica Viedma
🇦🇷Viedma, Río Negro, Argentina
Sanatorio Parque SA
🇦🇷Rosario, Santa Fe, Argentina
Centro Oncologico Korben
🇦🇷Buenos Aires, Argentina
Fundacion Centro Oncológico Riojano Integral para la Investigación y Prevención del Cáncer
🇦🇷La Rioja, Argentina
Centro de Diagnostico Investigacion y Tratamiento
🇦🇷Salta, Argentina
Campbelltown Hospital
🇦🇺Campbelltown, New South Wales, Australia
Concord Repatriation General Hospital
🇦🇺Concord, New South Wales, Australia
Nepean Cancer Centre
🇦🇺Kingswood, New South Wales, Australia
GenesisCare -North Shore Oncology
🇦🇺St Leonards, New South Wales, Australia
Calvary Mater Newcastle Hospital
🇦🇺Waratah, New South Wales, Australia
Toowoomba Hospital
🇦🇺Toowoomba, Queensland, Australia
Liga Norte-Riograndense Contra O Cancer
🇧🇷Natal, Rio Grande Do Norte, Brazil
Princess Alexandra Hospital
🇦🇺Woolloongabba, Queensland, Australia
Cancer Research South Australia
🇦🇺Adelaide, South Australia, Australia
Peter MacCallum Cancer Centre
🇦🇺Melbourne, Victoria, Australia
The Alfred Hospital
🇦🇺Melbourne, Victoria, Australia
Medizinische Universitaet Graz
🇦🇹Graz, Austria
Klinikum Klagenfurt am Woerthersee
🇦🇹Klagenfurt, Austria
Universitaetsklinikum Krems
🇦🇹Krems, Austria
Landeskrankenhaus Salzburg
🇦🇹Salzburg, Austria
Klinikum Wels - Grieskirchen GmbH
🇦🇹Wels, Austria
Chirec - Delta Ziekenhuis
🇧🇪Auderghem, Belgium
Algemeen Ziekenhuis Maria Middelares
🇧🇪Gent, Belgium
Universitair Ziekenhuis Leuven - Campus Gasthuisberg
🇧🇪Leuven, Belgium
Centre Hospitalier Regional de la Citadelle
🇧🇪Liège, Belgium
Algemeen Ziekenhuis Sint-Maarten
🇧🇪Mechelen, Belgium
Núcleo de Oncologia da Bahia
🇧🇷Salvador, Bahia, Brazil
Hospital Sirio Libanes
🇧🇷Brasilia, Distrito Federal, Brazil
Oncoclinicas Onco Vida Distrito Federal
🇧🇷Brasilia, Distrito Federal, Brazil
Hospital Evangelico de Cachoeiro de Itapemirim
🇧🇷Cachoeiro de Itapemirim, Espírito Santo, Brazil
Nucleo de Ensino Pesquisa e Inovacao Mario Penna
🇧🇷Belo Horizonte, Minas Gerais, Brazil
Centro de Tratamento Oncologico - Cto
🇧🇷Belem, Pará, Brazil
Instituto de Medicina Integral Professor Fernando Figueira - Imip
🇧🇷Recife, Pernambuco, Brazil
Associação Beneficente de Canoas
🇧🇷Canoas, Rio Grande Do Sul, Brazil
Irmandade da Santa Casa de Misericordia de Porto Alegre
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Centro de pesquisa em oncologia Hospital Ana Nery
🇧🇷Santa Cruz do Sul, Rio Grande Do Sul, Brazil
Clinica de Neoplasias Litoral
🇧🇷Itajai, Santa Catarina, Brazil
Fundacao Pio 12 Hospital de Amor de Barretos
🇧🇷Barretos, São Paulo, Brazil
Santa Casa de Misericordia de Santos - Iscms
🇧🇷Santos, São Paulo, Brazil
Beneficencia Portuguesa de Sao Paulo - Bp
🇧🇷Sao Paulo, São Paulo, Brazil
Fundacao Antonio Prudente
🇧🇷Sao Paulo, São Paulo, Brazil
Hospital de Base de Sao Jose do Rio Preto
🇧🇷São José do Rio Preto, São Paulo, Brazil
Oncoclinicas Rio de Janeiro S A
🇧🇷Rio de Janeiro, Brazil
Instituto de Ensino e Pesquisa Sao Lucas Iep Sao Lucas
🇧🇷São Paulo, Brazil
Instituto do Cancer do Estado de Sao Paulo Octavio Frias de Oliveira Icesp
🇧🇷São Paulo, Brazil
Multiprofile Hospital for Active Treatment - Uni Hospital OOD
🇧🇬Panagyurishte, Bulgaria
University Multiprofile Hospital for Active Treatment Sveta Marina - Pleven OOD
🇧🇬Pleven, Bulgaria
Multiprofile Hospital for Active Treatment for Womens Health - Nadezhda OOD
🇧🇬Sofia, Bulgaria
Acibadem City Clinic University Multiprofile Hospital for Active Treatment Tokuda EAD
🇧🇬Sofia, Bulgaria
University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna - ISUL EAD
🇧🇬Sofia, Bulgaria
Queen Elizabeth II, Health Sciences Centre
🇨🇦Halifax, Nova Scotia, Canada
Sunnybrook Research Institute Sunnybrook Health Sciences Centre
🇨🇦Toronto, Ontario, Canada
McGill University Health Centre Glen Site
🇨🇦Montreal, Quebec, Canada
CIUSSS - du Nord-de-lIle-de-Montreal / Hopital Sacre-Coeur de Montreal
🇨🇦Montreal, Quebec, Canada
Institut Universitaire de cardiologie et de pneumologie de Quebec
🇨🇦Quebec City, Quebec, Canada
Allan Blair Cancer Centre
🇨🇦Regina, Saskatchewan, Canada
Saskatoon Cancer Centre
🇨🇦Saskatoon, Saskatchewan, Canada
James Lind Centro de Investigacion del Cancer
🇨🇱Temuco, Cautín, Chile
Clinica CIDO
🇨🇱Temuco, Cautín, Chile
Orlandi Oncologia
🇨🇱Santiago, Chile
Fundacion Arturo Lopez Perez
🇨🇱Santiago, Chile
Biocinetic
🇨🇱Santiago, Chile
Centro de Investigacion del Maule
🇨🇱Talca, Chile
The First Affiliated Hospital of Bengbu Medical University
🇨🇳Bengbu, Anhui, China
Anhui Chest Hospital
🇨🇳Hefei, Anhui, China
Chongqing University Cancer Hospital
🇨🇳Chongqing, Chongqing, China
Fujian Provincial Hospital
🇨🇳Fuzhou, Fujian, China
Fujian Cancer Hospital
🇨🇳Fuzhou, Fujian, China
Fujian Medical University Union Hospital
🇨🇳Fuzhou, Fujian, China
The First Affiliated Hospital of Xiamen University
🇨🇳Xiamen, Fujian, China
Zhongshan Hospital Xiamen University
🇨🇳Xiamen, Fujian, China
Gansu Province Cancer Hospital
🇨🇳Lanzhou, Gansu, China
Guangdong Provincial Peoples Hospital
🇨🇳Guangzhou, Guangdong, China
Affiliated Cancer Hospital and institute of Guangzhou Medical University
🇨🇳Guangzhou, Guangdong, China
Cancer Hospital of Shantou University Medical College
🇨🇳Shantou, Guangdong, China
Liuzhou Peoples Hospital
🇨🇳Liuzhou, Guangxi, China
Guangxi Medical University Cancer Hospital
🇨🇳Nanning, Guangxi, China
Hainan Cancer Hospital
🇨🇳Haikou, Hainan, China
Affiliated Hospital of Hebei University
🇨🇳Baoding, Hebei, China
Harbin Medical University Cancer Hospital
🇨🇳Harbin, Heilongjiang, China
AnYang Tumor Hospital
🇨🇳Anyang, Henan, China
The First Affiliated Hospital of Henan University of Science And Technology
🇨🇳Luoyang, Henan, China
Henan Cancer Hospital
🇨🇳Zhengzhou, Henan, China
The First Affiliated Hospital of Zhengzhou University
🇨🇳Zhengzhou, Henan, China
Union Hospital Tongji Medical College Huazhong University of Science and Technology
🇨🇳Wuhan, Hubei, China
Tongji Hospital Tongji Medical College Of Hust
🇨🇳Wuhan, Hubei, China
Xiangyang Central Hospital
🇨🇳Xiangyang, Hubei, China
Xiangya Hospital Central South University
🇨🇳Changsha, Hunan, China
The Second Xiangya Hospital of Central South University
🇨🇳Changsha, Hunan, China
Nanjing Drum Tower Hospital
🇨🇳Nanjing, Jiangsu, China
Nanjing First Hospital
🇨🇳Nanjing, Jiangsu, China
Jiangxi Cancer Hospital
🇨🇳Nanchang, Jiangxi, China
The First Affiliated Hospital of Nanchang University
🇨🇳Nanchang, Jiangxi, China
Jilin Cancer Hospital
🇨🇳Changchun, Jilin, China
Cancer Hospital of Shandong First Medical University
🇨🇳Jinan, Shandong, China
Linyi Peoples Hospital
🇨🇳Linyi, Shandong, China
Weifang Peoples Hospital
🇨🇳Weifang, Shandong, China
Fudan University Shanghai Cancer Center
🇨🇳Shanghai, Shanghai, China
Shanxi Cancer Hospital
🇨🇳Taiyuan, Shanxi, China
The First Affiliated Hospital of Xi An JiaoTong University
🇨🇳Xi'an, Shanxi, China
Sichuan Cancer Hospital
🇨🇳Chengdu, Sichuan, China
West China Hospital of Sichuan University
🇨🇳Chengdu, Sichuan, China
Tianjin Medical University Cancer Institute and Hospital
🇨🇳Tianjin, Tianjin, China
Yunnan Cancer Hospital
🇨🇳Kunming, Yunnan, China
the First Affiliated Hospital Zhejiang University School of Medicine
🇨🇳Hangzhou, Zhejiang, China
Zhejiang Cancer Hospital
🇨🇳Hangzhou, Zhejiang, China
Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine
🇨🇳Hangzhou, Zhejiang, China
Nantong Tumor Hospital
🇨🇳Nantong, Zhejiang, China
Taizhou Hospital of Zhejiang Province
🇨🇳Taizhou, Zhejiang, China
Beijing Cancer Hospital
🇨🇳Beijing, China
Beijing Chest Hospital, Capital Medical University
🇨🇳Beijing, China
Fundacion Colombiana de Cancerologia Clinica Vida
🇨🇴Medellin, Antioquia, Colombia
Sociedad de Oncologia y Hematologia del Cesar
🇨🇴Valledupar, Cesar, Colombia
Instituto Nacional de Cancerologia
🇨🇴Bogota, Cundinamarca, Colombia
Centro de Tratamiento e Investigación sobre Cancer Luis Carlos Sarmiento Angulo Ctic
🇨🇴Bogotá, Cundinamarca, Colombia
Instituto Medico de Alta Tecnologia sas - Imat sas
🇨🇴Monteria, Córdoba, Colombia
Oncologos del Occidente SAS
🇨🇴Pereira, Risaralda, Colombia
Fundacion cardiovascular de Colombia
🇨🇴Bucaramanga, Santander, Colombia
Centro Cancerologico del Caribe LTDA CECAC
🇨🇴Barranquilla, Colombia
Fakultni nemocnice Brno
🇨🇿Brno, Czechia
Fakultni nemocnice Olomouc
🇨🇿Olomouc, Czechia
Fakultni nemocnice Plzen
🇨🇿Plzen, Czechia
Aarhus Universitetshospital
🇩🇰Aarhus N, Denmark
Rigshospitalet
🇩🇰Copenhagen, Denmark
Regionshospitalet Godstrup
🇩🇰Herning, Denmark
Sonderborg Sygehus
🇩🇰Sonderborg, Denmark
Vejle Sygehus
🇩🇰Vejle, Denmark
Centre Hospitalier Regional Universitaire de Besancon - Hopital Jean Minjoz
🇫🇷Besancon, France
Centre Hospitalier Universitaire Ambroise Pare
🇫🇷Boulogne-Billancourt, France
Centre Hospitalier Universitaire de Caen - Hopital Cote de Nacre
🇫🇷Caen, France
Centre Hospitalier Intercommunal de Creteil
🇫🇷Creteil, France
Centre Hospitalier Departemental Les Oudairies
🇫🇷La Roche sur Yon, France
Centre Hospitalier - Le Mans
🇫🇷Le Mans, France
Centre Hospitalier Régional Universitaire de Lille - Institut Coeur Poumon
🇫🇷Lille Cedex, France
Centre Hospitalier Universitaire Nord
🇫🇷Marseille Cedex 20, France
Centre de Cancerologie du Grand Montpellier-Clinique Clementville
🇫🇷Montpellier, France
Hopital prive du Confluent
🇫🇷Nantes Cedex 2, France
Centre Antoine Lacassagne
🇫🇷Nice, France
Hopital Universitaire Caremeau
🇫🇷Nimes cedex 9, France
Hopital Tenon
🇫🇷Paris Cedex 20, France
Institut Curie
🇫🇷Paris, France
Groupe Hospitalier Paris Saint Joseph
🇫🇷Paris, France
Hopital Cochin
🇫🇷Paris, France
Centre Hospitalier Universitaire de Bordeaux - Hopital Haut Leveque
🇫🇷Pessac Cedex, France
Centre Hospitalier Universitaire de Poitiers - Hopital la Miletrie
🇫🇷Poitiers CEDEX, France
Centre Hospitalier de Cornouaille
🇫🇷Quimper, France
Centre Hospitalier Universitaire de Reims - Hopital Christian Cabrol
🇫🇷Reims Cedex, France
Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou
🇫🇷Rennes, France
Orszagos Koranyi Pulmonologiai Intezet
🇭🇺Budapest, Hungary
Centre Hospitalier Universitaire de Rouen - Hopital Charles Nicolle
🇫🇷Rouen Cedex, France
Centre Hospitalier Universitaire de Saint Etienne - Hopital Nord
🇫🇷Saint Priest en Jarez, France
Centre Hospitalier Universitaire de Strasbourg - Nouvel Hopital Civil
🇫🇷Strasbourg Cedex, France
Hopital d instruction des armees sainte anne
🇫🇷Toulon, France
Centre Hospitalier Universitaire de Toulouse - Hopital Larrey
🇫🇷Toulouse Cedex 9, France
Centre Hospitalier Regional Universitaire de Tours - Hopital Bretonneau
🇫🇷Tours Cedex 9, France
Hopital Nord Ouest Villefranche sur Saone
🇫🇷Villefranche Sur Saone Cedex, France
Gustave Roussy
🇫🇷Villejuif, France
Klinikum Chemnitz GmbH
🇩🇪Chemnitz, Germany
Asklepios Fachkliniken Muenchen Gauting
🇩🇪Gauting, Germany
Universitaetsmedizin Goettingen
🇩🇪Goettingen, Germany
Klinikverbund Allgaeu
🇩🇪Kempten, Germany
Klinikum der LMU Muenchen
🇩🇪Muenchen, Germany
251 General Airforce Hospital
🇬🇷Athens, Greece
Henry Dunant Hospital Center
🇬🇷Athens, Greece
Alexandra Hospital
🇬🇷Athens, Greece
Attikon University Hospital
🇬🇷Athens, Greece
Iaso Hospital
🇬🇷Athens, Greece
Metropolitan Hospital
🇬🇷Athens, Greece
Iaso General Clinic
🇬🇷Marousi, Greece
Theagenion Cancer Hospital
🇬🇷Thessaloniki, Greece
Agios Loukas Clinic
🇬🇷Thessaloniki, Greece
European Interbalkan Medical Center
🇬🇷Thessaloniki, Greece
Queen Mary Hospital, The University of Hong Kong
🇭🇰Hong Kong, Hong Kong
Princess Margaret Hospital
🇭🇰Kowloon, Hong Kong
Queen Elizabeth Hospital, Hong Kong
🇭🇰Kowloon, Hong Kong
Budapesti Uzsoki Utcai Korhaz
🇭🇺Budapest, Hungary
Farkasgyepui Tudogyogyintezet
🇭🇺Farkasgyepu, Hungary
Matrai Gyogyintezet
🇭🇺Gyongyos, Hungary
Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktatokorhaz
🇭🇺Gyor, Hungary
Fejer Varmegyei Szent Gyorgy Egyetemi Oktato Korhaz
🇭🇺Szekesfehervar, Hungary
Komarom-Esztergom Varmegyei Szent Borbala Korhaz
🇭🇺Tatabanya, Hungary
Reformatus Pulmonologiai Centrum
🇭🇺Torokbalint, Hungary
IRCCS Istituto Tumori Giovanni Paolo II
🇮🇹Bari, Italy
Azienda Ospedaliero Universitaria Policlinico G Rodolico - San Marco Presidio Ospedaliero G Rodolico
🇮🇹Catania, Italy
Azienda Ospedaliero Universitaria Careggi
🇮🇹Firenze, Italy
Istituto Romagnolo per lo Studio dei Tumori Dino Amadori
🇮🇹Meldola (FC), Italy
Fondazione IRCCS Istituto Nazionale dei Tumori
🇮🇹Milano, Italy
Fondazione IRCCS San Gerardo dei Tintori
🇮🇹Monza (MB), Italy
Azienda Ospedaliera di Rilievo Nazionale Specialistica dei Colli Monaldi
🇮🇹Napoli, Italy
Azienda Ospedaliero Universitaria Luigi Vanvitelli
🇮🇹Napoli, Italy
Azienda Ospedaliero-Universitaria di Parma
🇮🇹Parma, Italy
Azienda Ospedaliera di Perugia Ospedale Santa Maria della Misericordia
🇮🇹Perugia, Italy
Nagoya University Hospital
🇯🇵Nagoya-shi, Aichi, Japan
Hirosaki University Hospital
🇯🇵Hirosaki-shi, Aomori, Japan
Chiba Cancer Center
🇯🇵Chiba-shi, Chiba, Japan
National Cancer Center Hospital East
🇯🇵Kashiwa-shi, Chiba, Japan
National Hospital Organization Shikoku Cancer Center
🇯🇵Matsuyama-shi, Ehime, Japan
Ehime University Hospital
🇯🇵Toon-shi, Ehime, Japan
National Hospital Organization Kyushu Cancer Center
🇯🇵Fukuoka-shi, Fukuoka, Japan
Hospital of the University of Occupational and Environmental Health Japan
🇯🇵Kitakyushu-shi, Fukuoka, Japan
Kurume University Hospital
🇯🇵Kurume-shi, Fukuoka, Japan
Chugoku Central Hospital of Japan Mutual Aid Association of Public School Teachers
🇯🇵Fukuyama-shi, Hiroshima, Japan
National Hospital Organization Hokkaido Cancer Center
🇯🇵Sapporo-shi, Hokkaido, Japan
Kobe Minimally invasive Cancer Center
🇯🇵Kobe-shi, Hyogo, Japan
Takarazuka City Hospital
🇯🇵Takarazuka-shi, Hyogo, Japan
Kanazawa University Hospital
🇯🇵Kanazawa-shi, Ishikawa, Japan
St Marianna University Hospital
🇯🇵Kawasaki-shi, Kanagawa, Japan
Kanagawa Prefectural Hospital Organization Kanagawa Cancer Center
🇯🇵Yokohama-shi, Kanagawa, Japan
Kyoto University Hospital
🇯🇵Kyoto-shi, Kyoto, Japan
Miyagi Cancer Center
🇯🇵Natori-shi, Miyagi, Japan
Sendai Kousei Hospital
🇯🇵Sendai-shi, Miyagi, Japan
Niigata Cancer Center Hospital
🇯🇵Niigata-shi, Niigata, Japan
Okayama University Hospital
🇯🇵Okayama-shi, Okayama, Japan
Kansai Medical University Hospital
🇯🇵Hirakata-shi, Osaka, Japan
Osaka International Cancer Institute
🇯🇵Osaka-shi, Osaka, Japan
Kindai University Hospital
🇯🇵Osakasayama-shi, Osaka, Japan
National Hospital Organization Kinki-chuo Chest Medical Center
🇯🇵Sakai-shi, Osaka, Japan
Saitama Cancer Center
🇯🇵Kitaadachi-gun, Saitama, Japan
Shizuoka Cancer Center
🇯🇵Sunto-gun, Shizuoka, Japan
Juntendo University Hospital
🇯🇵Bunkyo-ku, Tokyo, Japan
The Cancer Institute Hospital of Japanese Foundation for Cancer Research
🇯🇵Koto-ku, Tokyo, Japan
Tottori University Hospital
🇯🇵Yonago-shi, Tottori, Japan
Wakayama Medical University Hospital
🇯🇵Wakayama-shi, Wakayama, Japan
National Hospital Organization Yamaguchi-Ube Medical Center
🇯🇵Ube-shi, Yamaguchi, Japan
Pusan National University Hospital
🇰🇷Busan, Korea, Republic of
National Cancer Center
🇰🇷Goyang-si Gyeonggi-do, Korea, Republic of
Gachon University Gil Hospital
🇰🇷Incheon, Korea, Republic of
Korea University Anam Hospital
🇰🇷Seoul, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Korea University Guro Hospital
🇰🇷Seoul, Korea, Republic of
Pusan National University Yangsan Hospital
🇰🇷Yangsan-si, Gyeongsangnam-do, Korea, Republic of
Pauls Stradins Clinical University Hospital
🇱🇻Riga, Latvia
Riga East Clinical University Hospital
🇱🇻Riga, Latvia
Hospital Tengku Ampuan Afzan
🇲🇾Kuantan, Pahang, Malaysia
Pantai Hospital Kuala Lumpur
🇲🇾Kuala Lumpur, Wilayah Persekutuan, Malaysia
University Malaya Medical Centre
🇲🇾Kuala Lumpur, Wilayah Persekutuan, Malaysia
Health Pharma Professional Research SA de CV
🇲🇽Mexico City, Distrito Federal, Mexico
Hospital Civil de Guadalajara Fray Antonio Alcalde
🇲🇽Guadalajara, Jalisco, Mexico
Hospital Universitario Dr Jose Eleuterio Gonzalez
🇲🇽Monterrey, Nuevo León, Mexico
Oncare
🇲🇽Monterrey, Nuevo León, Mexico
Actualidad Basada en la Investigación del Cáncer
🇲🇽Guadalajara, Mexico
Meander Medisch Centrum
🇳🇱Amersfoort, Netherlands
Universitair Medisch Centrum Groningen
🇳🇱Groningen, Netherlands
Sint Jansdal Ziekenhuis
🇳🇱Harderwijk, Netherlands
Maastricht Universitair Medisch Centrum
🇳🇱Maastricht, Netherlands
Elisabeth-TweeSteden Ziekenhuis
🇳🇱Tilburg, Netherlands
Isala Klinieken
🇳🇱Zwolle, Netherlands
Centro de Investigacion Vallesur
🇵🇪Arequipa, Peru
Oncosalud
🇵🇪Lima, Peru
Unidad de Investigación Clínica Internacional Sede San Borja
🇵🇪Lima, Peru
Hospital de Apoyo Departamental Maria Auxiliadora
🇵🇪Lima, Peru
Uniwersytecki Szpital Kliniczny w Bialymstoku
🇵🇱Bialystok, Poland
Centrum Pulmonologii i Torakochirurgii w Bystrej
🇵🇱Bystra, Poland
Szpitale Pomorskie Spolka z ograniczona odpowiedzialnoscia
🇵🇱Gdynia, Poland
Kantonsspital Aarau
🇨🇭Aarau, Switzerland
Szpital Specjalistyczny imienia Ludwika Rydygiera w Krakowie Sp zoo
🇵🇱Krakow, Poland
Instytut Centrum Zdrowia Matki Polki
🇵🇱Lodz, Poland
Uniwerystecki Szpital Kliniczny Nr 4 w Lublinie
🇵🇱Lublin, Poland
Med Polonia Sp zoo
🇵🇱Poznan, Poland
Wojewodzki Szpital im Sw Ojca Pio w Przemyslu
🇵🇱Przemysl, Poland
Specjalistyczny Szpital im dra Alfreda Sokolowskiego
🇵🇱Walbrzych, Poland
Narodowy Instytut Onkologii im Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy
🇵🇱Warszawa, Poland
Fundacao Champalimaud
🇵🇹Lisboa, Portugal
Hospital da Luz, SA
🇵🇹Lisboa, Portugal
Unidade Local de Saude de Santa Maria, EPE - Hospital Pulido Valente
🇵🇹Lisboa, Portugal
Hospital Cuf Tejo
🇵🇹Lisboa, Portugal
Unidade Local de Saude de Matosinhos, EPE - Hospital Pedro Hispano
🇵🇹Matosinhos, Portugal
Hospital Cuf porto
🇵🇹Porto, Portugal
Institutul Oncologic, Prof Dr Alexandru Trestioreanu
🇷🇴Bucuresti, Romania
Spitalul Universitar de Urgenta Bucuresti
🇷🇴Bucuresti, Romania
Institutul Oncologic Prof Dr Ion Chiricuta Cluj-Napoca
🇷🇴Cluj Napoca, Romania
SC Medisprof SRL
🇷🇴Cluj Napoca, Romania
Centrul de Oncologie Sf Nectarie SRL
🇷🇴Craiova, Romania
Institutul Regional de Oncologie Iasi
🇷🇴Iasi, Romania
Spitalul Municipal Ploiesti
🇷🇴Ploiesti, Romania
SC Oncomed SRL
🇷🇴Timisoara, Romania
National University Hospital
🇸🇬Singapore, Singapore
Tan Tock Seng Hospital
🇸🇬Singapore, Singapore
Hospital Regional Universitario de Malaga
🇪🇸Malaga, Andalucía, Spain
Kantonsspital Baden
🇨🇭Baden, Switzerland
Hospital Universitario Virgen del Rocio
🇪🇸Sevilla, Andalucía, Spain
Hospital Clinico Universitario Lozano Blesa
🇪🇸Zaragoza, Aragón, Spain
Hospital Universitario Insular de Gran Canaria
🇪🇸Las Palmas de Gran Canaria, Canarias, Spain
Hospital Universitario Marques de Valdecilla
🇪🇸Santander, Cantabria, Spain
Hospital del Mar
🇪🇸Barcelona, Cataluña, Spain
Hospital Universitari Vall d Hebron
🇪🇸Barcelona, Cataluña, Spain
Hospital Clinic i Provincial de Barcelona
🇪🇸Barcelona, Cataluña, Spain
Hospital de la Santa Creu i Sant Pau
🇪🇸Barcelona, Cataluña, Spain
Institut Catala d Oncologia Hospitalet Hospital Duran i Reynals
🇪🇸Hospitalet de Llobregat, Cataluña, Spain
Hospital Clinico Universitario de Valencia
🇪🇸Valencia, Comunidad Valenciana, Spain
Hospital Universitari i Politecnic La Fe
🇪🇸Valencia, Comunidad Valenciana, Spain
Complexo Hospitalario Universitario A Coruna Hospital Teresa Herrera
🇪🇸A Coruña, Galicia, Spain
Hospital Universitario Puerta de Hierro Majadahonda
🇪🇸Majadahonda, Madrid, Spain
Fundacion Jimenez Diaz
🇪🇸Madrid, Spain
Hospital Clinico San Carlos
🇪🇸Madrid, Spain
Hospital Universitario La Paz
🇪🇸Madrid, Spain
Sahlgrenska Universitetssjukhuset
🇸🇪Goteborg, Sweden
Gavle Sjukhus
🇸🇪Gävle, Sweden
Norrlands Universitetssjukhus
🇸🇪Umea, Sweden
Universitaetsspital Basel
🇨🇭Basel, Switzerland
Universitaetsspital Zuerich
🇨🇭Zuerich, Switzerland
China Medical University Hospital
🇨🇳Taichung, Taiwan
Veterans General Hospital - Taichung
🇨🇳Taichung, Taiwan
National Cheng Kung University Hospital
🇨🇳Tainan, Taiwan
Chi Mei Hospital, Liouying
🇨🇳Tainan, Taiwan
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Taipei Veterans General Hospital
🇨🇳Taipei, Taiwan
Linkou Chang Gung Memorial Hospital
🇨🇳Taoyuan, Taiwan
Ondokuz Mayis Universitesi Tip Fakultesi Hastanesi
🇹🇷Samsun, Turkey
Queen Elizabeth Hospital Birmingham
🇬🇧Birmingham, United Kingdom
Vajira Hospital
🇹🇭Bangkok, Thailand
King Chulalongkorn Memorial Hospital
🇹🇭Bangkok, Thailand
Phramongkutklao Hospital
🇹🇭Bangkok, Thailand
Maharaj Nakorn Chiang Mai Hospital
🇹🇭Chiang Mai, Thailand
Srinagarind Hospital
🇹🇭Khon Kaen, Thailand
Banphaeo General Hospital
🇹🇭Samut Sakhon, Thailand
Songklanagarind Hospital
🇹🇭Songkla, Thailand
Medical Park Seyhan Hastanesi
🇹🇷Adana, Turkey
Hacettepe Universitesi Tip Fakultesi Hastanesi
🇹🇷Ankara, Turkey
Gazi Universitesi Saglik Arastirma ve Uygulama Merkezi Gazi Hastanesi
🇹🇷Ankara, Turkey
Ankara Bilkent Sehir Hastanesi
🇹🇷Ankara, Turkey
Akdeniz Universitesi Tip Fakultesi
🇹🇷Antalya, Turkey
Aydin Adnan Menderes Universitesi Tip Fakultesi
🇹🇷Aydin, Turkey
Pamukkale Universitesi Tip Fakultesi Hastanesi
🇹🇷Denizli, Turkey
Istanbul Universitesi Cerrahpasa Tip Fakultesi
🇹🇷Istanbul, Turkey
Memorial Bahcelievler Hastanesi
🇹🇷Istanbul, Turkey
Bagcilar Medipol Mega Universite Hastanesi
🇹🇷Istanbul, Turkey
Goztepe Prof Dr Suleyman Yalcin Sehir Hastanesi
🇹🇷Istanbul, Turkey
Marmara Universitesi Tip Fakultesi Hastanesi
🇹🇷Istanbul, Turkey
Izmir Ekonomi Universitesi Medical Point Hastanesi
🇹🇷Izmir, Turkey
Raigmore Hospital
🇬🇧Inverness, United Kingdom
Royal Marsden Hospital
🇬🇧Sutton, United Kingdom
Mount Vernon Cancer Centre
🇬🇧Northwood, United Kingdom
Nottingham City Hospital
🇬🇧Nottingham, United Kingdom
Torbay Hospital
🇬🇧Torquay, United Kingdom
Royal Cornwall Hospital
🇬🇧Truro, United Kingdom