ACTRN12611001199909RecruitingPhase 3
The effect of azithromycin and hypertonic saline on quality of life, lung function and exercise capacity in adults with non-cystic fibrosis bronchiectasis
Trial Snapshot
- Phase
- Phase 3
- Status
- Recruiting
- Sponsor
- Sydney Local Health District
- Enrollment
- 130
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
- Allocation
- Randomised controlled trial
- Primary Purpose
- Treatment
- Masking
- Blinded (masking used)
Eligibility Criteria
- Ages
- 18 Years to o limit (—)
- Sex
- All
Inclusion Criteria
- •Non-cystic fibrosis bronchiectasis (defined as chronic cough and sputum production with at least two lobes involved on HRCT);
- •Aged at least 18 years;
- •FEV1 within 10% of the best outpatient value during the previous six months;
- •At least two weeks since antibiotics for a respiratory exacerbation
Exclusion Criteria
- •Inability to provide informed consent;
- •Known allergy to macrolide therapy or quinine sulphate;
- •Thrombocytopaenia;
- •Immune thrombocytopaenia purpura (ITP);
- •Hypertonic saline or mannitol therapy in the previous two weeks;
- •Macrolide therapy in the previous four weeks;
- •Use of drugs contra-indicated by macrolide therapy;
- •FEV1<30% predicted;
- •Current smoking;
- •Unstable coronary heart disease;
- •Immunodeficiency;
- •Renal failure;
- •Severe liver disease;
- •Cerebrovascular disease;
- •Previous organ transplant;
- •Current or intended pregnancy in the following seven months;
- •Participation in another clinical trial in the previous 30 days or intended in the following seven months;
- •Non-tuberculous mycobacterium identified in sputum culture
Investigators
Similar Trials
Completed
Phase 3
Effect of Azithromycine (AZM) on gingival overgrowthgingival enlargement.gingival fibromatosisIRCT2017040529321N2Vice Chancellor for Research, Kerman university of medical sciences24
Completed
Not Applicable
Evaluation the effect of azithromycin oral suspension on the mucositis in patients undergoing Hematopoietic Stem Cell TransplantatioIRCT201603093210N13Maria Tavakoli-Ardakani60
Active, not recruiting
Phase 1
Early Treatment to Patients with Coronavirus (COVID)This trial will investigate infection with coronavirus (COVID-19) in patients who are admitted to hospitalMedDRA version: 23.0Level: PTClassification code 10051905Term: Coronavirus infectionSystem Organ Class: 10021881 - Infections and infestationsMedDRA version: 20.0Level: PTClassification code 10070255Term: Coronavirus test positiveSystem Organ Class: 10022891 - InvestigationsEUCTR2020-001198-55-DKChronic Obstructive Pulmonary Disease Trial Network (COP:TRIN)117
Recruiting
Phase 3
Comparison of the Effectiveness of Azithromycin and Erythromycin on the rate of clinical chorioamnionitis and Latency period up to termination of pregnancy in women with Preterm Premature Rupture of Membrane pregnancyIRCT20240513061769N1Zanjan University of Medical Sciences120
Completed
Not Applicable
Azithromycin's effect on periodontitisChronic periodontitis.Chronic pericoronitis Periodontitis: NOS complex simplexIRCT2014071518493N1Zahedan University of Medical Sciences40