Embryo Developmental Capacity After Egg Banking in an Ovum Donation Program
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 625
- 试验地点
- 1
- 主要终点
- Mean outcome measures will be survival, fertilization and blastocyst rates and clinical outcome.
研究概览
简要总结
For an efficient "egg banking" system, an equally efficient cryopreservation strategy that ensures the viability of the oocytes is required. Very recently, improved and new methods are yielding satisfactory results. In particular, vitrification is providing excellent results for both survival and clinical outcomes. However, to evaluate the over all out come there are other parameters to be considered. In this sense, capacity development of embryos generated after oocyte vitrification is a major factor when assessing the viability of vitrified oocytes. Accordingly, the evaluation of the capacity of vitrified oocytes to reach the blastocyst stage will be highly valuable to fully assess the effectiveness of the "egg banking" and its contribution to ovum donation programs.
The aim of this study is to evaluate the developmental capacity of vitrified oocytes by their ability to reach the blastocyst stage. The study includes oocyte donation cycles conducted with vitrified versus fresh oocytes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years(Adult)
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •18-35 year old
- •Normal response (8-15 follicles) to long protocol of ovarian stimulation with hCG
- •Donors with normal menstrual cycles (21-35 day duration)
- •Donors with BMI between 18-25 Kg/m2
排除标准
- •Donors with two or more previous miscarriages
- •Polycystic ovary syndrome
- •Donors with antecedents of poor embrionary quality not attributed to masculine factor
- •Donors with drop of estradiol of more than 10% or estradiol plateau.
- •Donors with a high response>20 oocytes and or levels above 3000pg/ml of estradiol the day of the administration of chorionic gonadotrophin (hCG)
研究组 & 干预措施
fresh
Embryo transfer with fresh oocytes
干预措施: IVF (Other)
Frozen
Embryo transfer with vitrified oocytes
干预措施: Oocyte Vitrification (Other)
结局指标
主要结局
Mean outcome measures will be survival, fertilization and blastocyst rates and clinical outcome.
时间窗: 10 months
次要结局
未报告次要终点
研究者
Carlos Simon
Dr. Carlos Simon MD PhD
Instituto Valenciano de Infertilidad, IVI VALENCIA
