Academic Investigational Study of Acute Effects of Vigorous-intensity Aerobic Exercise on Glymphatic Flow in Healthy Adults
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- MREG cardiovascular pulse wavefront
研究概览
简要总结
This study investigates changes in glymphatic flow in the brain acutely after vigorous-intensity steady-state aerobic exercise. Twenty subjects (10 male and 10 female) perform 25 minute submaximal cycle ergometry exercise and the changes in the glymphatic flow and cerebral perfusion are evaluated using a variety of MRI sequences (e.g. MREG).
详细描述
The glymphatic system is a drainage system for the brain to help maintain fluid balance and extract waste metabolites. Glymphatic system function (healthy glymphatic flow) may prevent accumulation of harmful substances and therefore slow down the onset of neurodegenerative diseases.
The hypothesis is, that glymphatic flow could be increased through exercise and enhanced cerebral arterial pulsality, which might explain some of the brain health benefits of exercise proven in epidemiological studies. This study indirectly investigates the acute changes in the glymphatic flow acutely after aerobic exercise using MREG that measures pulse wave propagation as an indirect surrogate marker for glymphatic flow.
Twenty healthy subjects (n=20, 10 male, 10 female, age 18-45 years) will perform 25 minute 70%VO2max cycle ergometry exercise. The glymphatic flow and cerebral perfusion will be measured using magnetic resonance imaging sequences before and after exercise. The glymphatic flow is measured using 10 Hz fMRI technique called magnetic resonance encephalography (MREG). In addition, perfusion MRI is used to evaluate changes in brain perfusion.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-45
- •BMI 18-30
- •Resting Blood pressure < 140/90 mmHg
排除标准
- •History of a cardiac event
- •Insulin or medically treated diabetes
- •Any chronic disease or condition that could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results
- •Presence of ferromagnetic objects that would make MR imaging contraindicated
- •Claustrophobia
- •Abundant use of alcohol
- •Use of narcotics
- •Smoking of tobacco or consuming snuff tobacco
- •Diagnosed depressive or bipolar disorder
- •Abnormalities in resting ECG (revised by the study physician)
- •Pregnancy
结局指标
主要结局
MREG cardiovascular pulse wavefront
时间窗: 3 hours
Is processed into three-dimensional vector fields and used as an assessment of glymphatic flow, scanned once before and multiple times after exercise intervention in 5-minute sequences
次要结局
- Cerebral perfusion fMRI(3 hours)
- Heart rate (HR)(3 hours)
- Blood pressure (BP)(3 hours)
研究者
Ilkka Heinonen
Adjunct Professor, Department of Clinical Medicine
Turku University Hospital