Culturing TM Cells From Primary Open-angle Glaucoma Patient Biopsies
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 2
- 主要终点
- Efficacy of new glaucoma medications to reduce TM cellular pathologies associated with the disease glaucoma.
研究概览
简要总结
In this study, the investigators will collect tissue from patients undergoing trabeculectomy for primary open-angle glaucoma treatment. This tissue would normally be discarded. These trabecular meshwork (TM) cells can be cultured and used experimentally to better understand the mechanisms of glaucoma. These TM biopsies will be cultured on the same day as the trabeculectomy using established techniques.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients having glaucoma and undergoing a trabeculotomy
- •Sign ICF (Informed Consent Form)
排除标准
- 未提供
结局指标
主要结局
Efficacy of new glaucoma medications to reduce TM cellular pathologies associated with the disease glaucoma.
时间窗: 6 weeks
TM cell biopsy samples from patients with glaucoma will be harvested and cultured in a laboratory setting to grow primary human TM cells. These cells will be used to test different medications, looking at the medications ability to reduce cellular pathologies commonly seen in TM tissue of patients with glaucoma. Pathologies include myocilin aggregation, and cell death. This will help researchers to determine the most effective compounds in treating glaucoma.
次要结局
- Cultured TM cell toxicity caused by new glaucoma medications(6 weeks)