ocal Sleep” in the Awake Brain: An Underlying Cause of Neurobehavioural Deficits in Obstructive Sleep Apnea?

Woolcock Institute of Medical Research0 个研究点目标入组 32 人开始时间: 2019年4月8日最近更新: 2023年3月13日

适应症

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•The participant's apnea-hypopnea index (AHI) must be greater than or equal to 15/hr to be eligible for the study. The symbol has been replaced with text below.
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•Males and females;
•Community-dwelling aged 35-65 years;
•Polysomnography confirmed moderate to severe OSA based on the apnea-hypopnea index (AHI) greater than or equal to 15/hr;
•Able to give informed consent;
•Fluent in English;
•Established CPAP users for a duration of at least 3 months (on average 4 hours use per night on at least 5 nights per week)
•Ability to perform neurobehavioural tests and driving simulator task.
•Current driver’s license
•Vulnerable to driving impairment without CPAP therapy/upon withdrawal of therapy, Assessed via positive response(s) to questions reporting driving accidents or impairments prior to established CPAP therapy, and/or physician's opinion.

•Clinically significant co-morbidity;
•Major neurological problems (e.g. stroke, epilepsy, head injury);
•Severe mental health disorder (e.g. current major depression, schizophrenia, bipolar disorder);
•Regular use of sleep-affecting medication; benzodiazepines, opioids, antidepressants.
•Shift worker or have traveled overseas within the last 2 weeks.
•Professional drivers.
•Sleep physician has advised against CPAP withdrawal

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