NL-OMON31343已完成不适用
Transient myeloproliferative disease in children with Down syndrome Part A: Screening newborns with Down syndrome for TMD Part B: Treatment and follow-up of children with Down syndrome and TMD - TMD in children with Down syndrome
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 811
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 2 至 11（—）
入选标准
- •Inclusion criteria part A:
- •- Newborns with Down syndrome born in the Netherlands
- •- Diagnosis between 01-07-2007 and 01-07-2012
- •- Age at peripheral blood sampling below 4 weeks
- •- Patients with demonstrable transient myeloid leukemia elsewhere are also eligible, even if no blasts can be detected in the peripheral blood
- •- signed informed consent;Inclusion criteria part B:
- •- proven TMD
- •- Down syndrome
- •- detectable GATA1-mutation in leukemic cells
- •- age below 3 months
- •- infromed consent
排除标准
- •Key exclusion criteria, part A:
- •- no consent,
- •- no confirmation of diagnosis of Down syndrome,
- •- complications which prohibit the analysis of a peripheral blood sample.;Key exclusion criteria, part B:
- •- complications or underlying disease that interferes with the possibility to treat
- •- presence of another hematological disease
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