Creation of a Probabilistic Atlas of Normal Cerebral Uptake of 18F-FDG in PET/MRI.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 39
- 试验地点
- 1
- 主要终点
- Creation, from a representative set of brain PET-MRI images of healthy subjects, of a probabilistic atlas of normal FDG uptake in healthy volunteers
研究概览
简要总结
With 18F-FDG PET, we have few atlases of normality allowing the realization of objective quantitative analyses. An atlas of normality is a probabilistic atlas of normal FDG uptake from a representative set of brain PET images of healthy subjects. This type of atlas is essential for intra- and inter-individual comparisons.
Accurate quantitative analysis of brain 18F-FDG PET images acquired on a hybrid PET system has been shown to require an institutional normal database for statistical analyzes (Akdemir et al., JNM 2017 and Della Rosa et al Neuroinformatics, 2014).
详细描述
This is a prospective, monocentric, non-randomized study, with no direct individual benefit since it involved healthy volunteers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or female aged 20 to 50
- •Absence of any history or cardiovascular, neurological or psychiatric deficit
- •Signed the informed consent
排除标准
- •Contraindication to the realization of an MRI or PET and to the injection of 18F-FDG
- •People using a pacemaker or insulin pump
- •People wearing a metal prosthesis or an intracerebral clip
- •People with intraocular metal splinters
- •People with a pathology considered incompatible for the production of the atlas according to the investigator
- •Pregnant women and breastfeeding women
- •Subject in period of exclusion.
研究组 & 干预措施
18F-FDG injection
Health volunteers with 18-F-FDG injection
干预措施: brain PET-MRI with 18F-FDG (Diagnostic Test)
结局指标
主要结局
Creation, from a representative set of brain PET-MRI images of healthy subjects, of a probabilistic atlas of normal FDG uptake in healthy volunteers
时间窗: 30 minutes after 18F-FDG injection
Evaluation of tracer activity at the cerebral level on the acquisition images
次要结局
未报告次要终点