NCT02148536已完成不适用
Effect of Transjugular Intrahepatic Portosystemic Shunt on Oxygenation in Cirrhotic Patients With Hepatopulmonary Syndrome
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 64
- 试验地点
- 1
- 主要终点
- Alveolar-arterial oxygen gradient (PA-a,O2)
研究概览
简要总结
To prospectively investigate the effect of transjugular intrahepatic portosystemic shunt (TIPS) on oxygenation in cirrhotic patients with hepatopulmonary syndrome (HPS).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Presence of cirrhosis
- •Alveolar-arterial oxygen gradient ≥ 15 mm Hg (≥ 20 mm Hg for age > 64 years)
- •Positive contrast-enhanced echocardiography
排除标准
- •Age of less than 18 years
- •Intrinsic cardiopulmonary disease
- •Malignancy
- •Active infection
- •Pregnancy
- •Previous shunt therapy
- •Refusal to participate
结局指标
主要结局
Alveolar-arterial oxygen gradient (PA-a,O2)
时间窗: 12 Weeks
次要结局
- Macroaggregated albumin (MAA) shunt fraction(12 Weeks)
- Exhaled nitric oxide (eNO)(12 Weeks)
研究者
研究点 (1)
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