Effect of Transjugular Intrahepatic Portosystemic Shunt on Oxygenation in Cirrhotic Patients With Hepatopulmonary Syndrome

Completed

• Conditions: Hepatopulmonary Syndrome
• Interventions: Procedure: Transjugular intrahepatic portosystemic shunt

• Registration Number: NCT02148536
• Lead Sponsor: West China Hospital

Brief Summary

To prospectively investigate the effect of transjugular intrahepatic portosystemic shunt (TIPS) on oxygenation in cirrhotic patients with hepatopulmonary syndrome (HPS).

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2014-05-21
• Study First Submitted QC: 2014-05-22
• Study First Posted: 2014-05-28
• Study Start: 2014-06
• Primary Completion: 2015-06
• Study Completion: 2015-09
• Status Verified: 2018-08
• Last Update Submitted: 2018-08-28
• Last Update Posted: 2018-08-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

• Presence of cirrhosis
• Alveolar-arterial oxygen gradient ≥ 15 mm Hg (≥ 20 mm Hg for age > 64 years)
• Positive contrast-enhanced echocardiography

Exclusion Criteria

• Age of less than 18 years
• Intrinsic cardiopulmonary disease
• Malignancy
• Active infection
• Pregnancy
• Previous shunt therapy
• Refusal to participate

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
HPS-TIPS group	Transjugular intrahepatic portosystemic shunt	-

Primary Outcome Measures

Name	Time	Method
Alveolar-arterial oxygen gradient (PA-a,O2)	12 Weeks

Secondary Outcome Measures

Name	Time	Method
Exhaled nitric oxide (eNO)	12 Weeks
Macroaggregated albumin (MAA) shunt fraction	12 Weeks

Trial Locations

Locations (1)

West China Hospital, Sichuan university; 🇨🇳 Chengdu, Sichuan, China