Autoreactivity Threshold Analysis in Lupus and Immune Thrombocytopenia (Checkpoints ITP and SLE)
- Conditions
- Systemic Lupus Erythematosus (SLE)Immune Thrombocytopenia (ITP)
- Interventions
- Other: Bliss-Believe
- Registration Number
- NCT03975361
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Brief Summary
The aim of this proposal is to test if anti-BAFF antibody can restore a normal threshold of tolerance in patients in two auto-immune diseases along the RITUX-PLUS study in immune thrombocytopenia, and along the Believe study in SLE. This work would help to conclude whether or not the 'double hit' therapy may help to reset the immune system toward a more tolerogenic profile.
The aim is to compare the polyreactivity and autoreactivity, of immature (central tolerance) and naïve B cells (peripheral tolerance) in the peripheral blood along the RITUX-PLUS STUDY and the BLISS BELIEVE study after treatment (B-cell reconstitution time).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 10
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Bliss-Believe Bliss-Believe Patients included in the BLISS-BELIEVE study (NCT03312907).
- Primary Outcome Measures
Name Time Method Number of polyreactive and autoreactive cells in immature and naïve B cells subsets in the peripheral blood 1 year Number of polyreactive and autoreactive cells in immature (central tolerance) and naïve B cells (peripheral tolerance) subsets in the peripheral blood along the RITUX-PLUS and the BLISS BELIEVE studies after treatment (reconstitution time).
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
Henri Mondor Hospital
🇫🇷Créteil, France
Pitie Salpetriere Hospital
🇫🇷Paris, France