Treatment of Periodontal Intra-bony Defects With a Volume Stable Collagen Matrix or Deproteinized Bovine Bone Mineral With 10% Collagen
- Conditions
- Periodontal Diseases
- Registration Number
- NCT06676826
- Lead Sponsor
- University of Bern
- Brief Summary
To compare the healing of intrabony periodontal defects treated with either open flap debridement and a volume-stable collagen matrix (VCMX) or a deproteinized bovine bone mineral with 10% collagen. The results will shed light on the clinical potential of VCMX in regenerative periodontal surgery and help to develop new treatment strategies.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 80
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Clinical attachment level (CAL) change 12 months Clinical attachment level (CAL) change in mm: the distance from the cemento-enamel junction to the bottom of the clinical periodontal pocket is being measured
- Secondary Outcome Measures
Name Time Method Microbiological analysis 1, 3, 12 weeks Quantification of the concentration of host-derived biomarkers (interleukin-1beta (IL-1b), IL-10, matrix-metalloproteinase- 8(MMP-8)) and periodontal bacterial species by means of gingival crevicular fluid and the biofilm sampling
Bleeding on probing (BoP) Baseline, 12 months Assessment of number of bleeding spots (percentage 0-100%) upon gentle probing of PPD at each test and control tooth site
Pocket probing depth (PPD) Baseline, 12 months With a periodontal probe with mm markings, the distance between the gingival margin and the bottom of the pocket will be measured
Trial Locations
- Locations (1)
University of Bern
🇨ðŸ‡Bern, Switzerland