ISRCTN26190474
Active, not recruiting
Phase 4
Antidepressants to prevent relapse in depression in older people (ANTLER 75+ Trial) – a double blind randomised controlled trial to evaluate the effectiveness and cost-effectiveness of continuing antidepressants
niversity College London0 sites430 target enrollmentAugust 22, 2024
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Depression
- Sponsor
- niversity College London
- Enrollment
- 430
- Status
- Active, not recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Aged 75 years old and over
- •2\. Either 2 or more previous episodes of depression treated with antidepressants (any antidepressant for any length of time) OR taking any antidepressant for at least 2 years at any time
- •3\. Currently has been taking either citalopram, sertraline or mirtazapine for at least 9 months, of which the last 3 months should be at the following doses: 20mg citalopram, 50 mg sertraline or 30mg mirtazapine. These 9 months can be included in the 2 years stated in inclusion 2
- •4\. Currently not depressed (scores \<5 on 15\-item Geriatric Depression Scale) and are now well enough to consider stopping the antidepressant
- •5\. Presence of a Study Partner (a family member, friend or formal caregiver) who sees or speaks to the participant at least once a week and is prepared to support the completion of outcome measures that involve recall of the previous 8 weeks
- •6\. Provides Informed Consent
Exclusion Criteria
- •1\. Diagnosis of Bipolar Disorder
- •2\. Diagnosis of Dementia (although people with mild cognitive impairment will be eligible for the trial)
- •3\. Currently prescribed a combination of antidepressants or an antidepressant and a mood stabiliser or an antipsychotic as this would indicate individuals with a history of more severe depression who would be at higher risk of relapse of depression
- •4\. Participation in another interventional study
- •5\. Participated in a CTIMP or a trial of psychological intervention in the preceding 3 months
Outcomes
Primary Outcomes
Not specified
Similar Trials
Active, not recruiting
Phase 1
Relapse prevention in patients with major depression treated with electroconvulsive therapy using a fixed dose range of escitalopram compared to a fixed dose of nortriptyline (DUAG-7)A randomised controlled 6 month double-blind study - Relapse prevention with escitalopram or nortriptyline following ECT (DUAG-7)EUCTR2008-003877-42-DKDanish University Antidepressant Group (DUAG)300
Active, not recruiting
Phase 1
Antidepressant for the prevention of DEPression following first episode Psychosis trialPatients with First Episode Psychosis.Therapeutic area: Psychiatry and Psychology [F] - Mental Disorders [F03]EUCTR2020-002787-32-GBniversity of Birmingham508
Active, not recruiting
Not Applicable
Preventing relapse of major depressive disorder in youth: Randomised Controlled Trial of a novel mindfulness-based cognitive online social therapyACTRN12619001412123Orygen246
Not yet recruiting
Not Applicable
Reducing relapse and recurrence in depression with continuation Cognitive Therapy.Recurrence or Relapse of Major Depression DisorderNL-OMON25030Arkin, mental health care institute Amsterdam,Department of Psychology of the University of Groningen,Vanderbilt University, Nashville,Vrije Universiteit Amsterdam, Faculteit der Geneeskunde Huisarts- en Verpleeghuisgeneeskunde,Trimbos Instituut, Innovation Centre of Mental Health & Technology,Vrije Universiteit Amsterdam, Faculteit der Aard- en Levenswetenschappen Gezondheidswetenschappen: Health Economics and Technology Assessment214
Not yet recruiting
Not Applicable
Reducing relapse and recurrence in depression with continuation Cognitive Therapy: a randomized controlled trial.depressive disorderdepression10027946NL-OMON40027Arkin (Amsterdam)214