Antidepressants to prevent relapse in depression in older people (ANTLER 75+ Trial) – a double blind randomised controlled trial to evaluate the effectiveness and cost-effectiveness of continuing antidepressants

niversity College London0 个研究点目标入组 430 人开始时间: 2024年8月22日最近更新: 2024年9月2日

适应症

试验速览

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•1. Aged 75 years old and over
•2. Either 2 or more previous episodes of depression treated with antidepressants (any antidepressant for any length of time) OR taking any antidepressant for at least 2 years at any time
•3. Currently has been taking either citalopram, sertraline or mirtazapine for at least 9 months, of which the last 3 months should be at the following doses: 20mg citalopram, 50 mg sertraline or 30mg mirtazapine. These 9 months can be included in the 2 years stated in inclusion 2
•4. Currently not depressed (scores <5 on 15-item Geriatric Depression Scale) and are now well enough to consider stopping the antidepressant
•5. Presence of a Study Partner (a family member, friend or formal caregiver) who sees or speaks to the participant at least once a week and is prepared to support the completion of outcome measures that involve recall of the previous 8 weeks
•6. Provides Informed Consent

•1. Diagnosis of Bipolar Disorder
•2. Diagnosis of Dementia (although people with mild cognitive impairment will be eligible for the trial)
•3. Currently prescribed a combination of antidepressants or an antidepressant and a mood stabiliser or an antipsychotic as this would indicate individuals with a history of more severe depression who would be at higher risk of relapse of depression
•4. Participation in another interventional study
•5. Participated in a CTIMP or a trial of psychological intervention in the preceding 3 months

发起方

niversity College London