A randomised controlled trial of biomarker-based exclusion of ventilator-associated pneumonia to improve antibiotic stewardship

ewcastle Upon Tyne Hospitals NHS Trust and University of Newcastle Upon Tyne (UK)0 sites159 target enrollmentAugust 22, 2013

Overview

Phase: 未知
Intervention: Not specified
Conditions: Not specified
Sponsor: ewcastle Upon Tyne Hospitals NHS Trust and University of Newcastle Upon Tyne (UK)
Enrollment: 159
Status: Completed
Last Updated: 6 years ago

Registry

who.int

Start Date

August 22, 2013

End Date

November 25, 2016

Last Updated

6 years ago

Study Type

Interventional

Sex

All

Sponsor

ewcastle Upon Tyne Hospitals NHS Trust and University of Newcastle Upon Tyne (UK)

•Current inclusion criteria as of 27/11/2013:
•1\. Age 18 years or over
•2\. Mechanically ventilated for 48hrs
•3\. New or worsening changes on chest x\-ray or CT scan of the lungs
•4\. Two or more from:
•4\.1\. Temperature \<35ºC or \>38ºC
•4\.2\. Blood white cell count \<4x10\*9/L or \>11x10\*9/L
•4\.3\. Purulent tracheal secretions
•5\. The patient is considered suitable for early discontinuation of antibiotics
•Target Gender: Male \& Female ; Lower Age Limit 18 years

•1\. PaO2 \<8kPa on FiO2 \>0\.7
•2\. Positive end\-expiratory pressure \>15 cmH2O
•3\. Peak airway pressure \>35 cmH2O
•4\. Heart rate \>140 bpm
•5\. Mean arterial pressure \<65 mmHg
•6\. Bleeding diathesis (including platelet count \<20x10\*9 per litre of blood or international normalised ratio (INR) \>3\)
•7\. Poorly controlled intracranial pressure (\>20 mmHg)
•8\. ICU consultant deems procedure not to be safe
•9\. Previous BAL as part of this study
•10\. Consent declined