Early Mechanical Ventilation for Guillain Barré Syndrome
Phase 2
Completed
- Conditions
- Guillain Barré SyndromeAcute Respiratory Failure
- Interventions
- Procedure: physiotherapy and oxygen if neededProcedure: mechanical ventilation
- Registration Number
- NCT00167622
- Lead Sponsor
- University of Versailles
- Brief Summary
The purpose of this study is to determine whether early mechanical ventilation can prevent hospital acquired pneumonia in adults with Guillain Barré Syndrome.
- Detailed Description
Hospital acquired pneumonia is a common and severe complication of Guillain Barré Syndrome. Several factors have been recognized as predictors of respiratory failure in adults with Guillain Barré Syndrome. They include a time from disease onset and patient admission of less seven days, inability to lift head, impaired swallowing and a forced vital capacity of less than 60% of predictive value. We reasonned that early mechanical ventilation may prevent aspiration which is likely the main cause of pneumonia in these patients.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
- Guillain Barré Syndrome
- Age of 18 years old or more
- Inability to lift head
- Time from onset of motor deficit less than 7 days
- Written informed consent
Exclusion Criteria
- Glasgow coma score of less than 8
- Unstable hemodynamic status
- Current pneumonia
- Pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 1 physiotherapy and oxygen if needed Physiotherapy, oxygen as needed 2 mechanical ventilation Mechanical ventilation
- Primary Outcome Measures
Name Time Method Rate of hospital acquired pneumonia from randomization to study day 90 Day 90
- Secondary Outcome Measures
Name Time Method Time on a ventilator Day 90 Hospital length of stay Day 90 Tolerance Day 90 Intensive care unit lenght of stay Day 90
Trial Locations
- Locations (1)
Raymond Poincaré Hospital
🇫🇷Garches, France