Maternal Key Nutritional Factors and Offspring's Atopic Dermatitis (MKNFOAD)
- Conditions
- Atopic Dermatitis
- Interventions
- Other: maternal biological folate levelOther: maternal biological Vitamin D level
- Registration Number
- NCT02889081
- Lead Sponsor
- Children's Hospital of Fudan University
- Brief Summary
The study is a prospective birth cohort study and the purpose is to describe the status of maternal key nutrients(eg. folate and vitamin D) supplementation among pregnancies at early gestation in Shanghai, to find out the association between the level of serum key nutrients and atopic dermatitis (AD) in offsprings during 6 months.
- Detailed Description
This study based on Shanghai pregnancy population is a prospective birth cohort. The investigators obtain the data of participants' folic acid and vitamin D supplement intake through the questionnaire at 12-14 gestational weeks. And the investigators collect participants' blood samples during gestation to directly detect the biological exposure levels of folate and vitamin D. In the follow-up, skin barrier function is evaluated at time of infant 24-48 hours, 42 days and 6 months. During 6 months from birth, the incidence of AD is investigated on offsprings. This cohort study is aimed to (1) clarify the association between prenatal key nutrients with offspring AD; (2) assess the role of maternal key nutrients in the skin barrier of offsprings. It will be a good evidence for the AD prevention and a meaningful protocol to reduce the incidence of AD by its unique design.Univariate and multivariate association analyses will be performed to identify risk factors to AD by using multivariate logistic regression model.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 487
- Mother plans to proceed prenatal care and delivery in Minhang Maternal and Children Health Care Hospital
- Offspring plans to stay in Shanghai until 6 months and proceed follow-up in Children's Hospital of Fudan University
- none
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description infants from birth cohort with AD maternal biological Vitamin D level maternal biological folate level and maternal biological vitamin D level and offspring's incidence of suffering from atopic dermatitis infants from birth cohort without AD maternal biological Vitamin D level maternal biological folate level and maternal biological vitamin D level and offspring's incidence of not suffering from atopic dermatitis infants from birth cohort with AD maternal biological folate level maternal biological folate level and maternal biological vitamin D level and offspring's incidence of suffering from atopic dermatitis infants from birth cohort without AD maternal biological folate level maternal biological folate level and maternal biological vitamin D level and offspring's incidence of not suffering from atopic dermatitis
- Primary Outcome Measures
Name Time Method Infant atopic dermatitis incident of AD during 6 months after birth, diagnosis confirmed based on disease history till 12 months Disease diagnosis according to the criteria of Williams
- Secondary Outcome Measures
Name Time Method Maternal folic acid supplement intake 12-14 gestational weeks Questionnaire survey will be used to obtain the data of maternal supplement intake
Infant skin barrier function (Stratum corneum hydration, SCH) infant 6 months old SCH will be evaluated by the device of Multi Probe Adapter 4.
Maternal serum folate level 34-36 gestational weeks Serum sample collected at different trimesters will be used for evaluation
Infant skin barrier function (Transepidermal Water Loss, TEWL） infant 6 months old TEWL will be evaluated by the device of Multi Probe Adapter 4.
Maternal serum Vitamin A level 12-14 gestational weeks Serum sample collected at different trimesters will be used for evaluation
Child atopic dermatitis from 2 years old to 5 years old from 2 years old to 5 years old Disease diagnosis according to the criteria of Williams
Maternal RBC folate level 12-14 gestational weeks Whole blood sample collected will be used for evaluation
Maternal vitamin D supplement intake 12-14 gestational weeks Questionnaire survey will be used to obtain the data of maternal supplement intake
Infant atopic dermatitis incidence by 1year old from birth , to 12months old Disease diagnosis according to the criteria of Williams
Infant skin barrier function (sebum content) infant 6 months old Sebum content will be evaluated by the device of Multi Probe Adapter 4.
Maternal serum Vitamin E level 12-14 gestational weeks Serum sample collected at different trimesters will be used for evaluation
Maternal serum vitamin D level 34-36 gestational weeks Serum sample collected at different trimesters will be used for evaluation
Infant skin barrier function (skin surface pH) infant 6 months old Skin pH will be evaluated by the device of Multi Probe Adapter 4.
Child atopic dermatitis from 1 year old to 2 years old from 1 year old to 2 years old Disease diagnosis according to the criteria of Williams
Trial Locations
- Locations (1)
Children Hospital of Fudan University
🇨🇳Shanghai, China