Effect of Calcium -Vitamin D and Alendronate on serum Dickkopf-1( Dkk-1) and Osteoprotegerin(OPG) in women with osteoporosis
Not Applicable
Completed
- Conditions
- osteoporosis.idiopathic osteoporosis
- Registration Number
- IRCT201201238809N1
- Lead Sponsor
- Research vice chancellor of Tabriz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 72
Inclusion Criteria
1.Menopause women that on the basis of the results obtained in densitometry according to the WHO criteria,have osteoporosis (Tscore below -2.5)at least in one of the two site(hip and spine).
Exclusion criteria:
1.Use of glucocorticoids or other medications that affect bone metabolism and density( cytotoxic drugs and anticoagulants).
2.Patients treated with Calcium or Vit D or both.
3.History of malignant disease.
4.Disease that cause secondary osteoporosis,such as intestinal,hepatic,hematologic,kidney disease;rheumatologic disease (such as RA,SLE) and endocrine disease (such as cushing syndrome,hypogonadism).
5.Presence of advanced osteoarthritis in physical examination.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Dickkopf-1. Timepoint: prior to initiating therapy and 4 months later. Method of measurement: ELISA method.;Osteoprotegerin. Timepoint: prior to initiating therapy and 4 months later. Method of measurement: ELISA method.
- Secondary Outcome Measures
Name Time Method