Airway obstruction in children with congenital mandibular hypoplasia.

Recruiting

Conditions: Craniofaciale afwijkingen
small lower jaw
underdevelopment of the lower jaw

Registration Number: NL-OMON37722

Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 313

Inclusion Criteria

Study Population 1a:
- Age between 0 and 3 months
- Presence of a congenital mandibular hypoplasia;Study Population 1b:
- Age between 3 months and 18 years old
- Presence of congenital mandibular hypoplasia;Study Population 2:
- Below the age of 18 years
- 3D CT-scan of the head as part of regular patient care;Control Population 1a:
- Age below 3 months
- Presence of cleft palate
- No congenital mandibular hypoplasia;Control Population 1b:
- Age between 3 months and 18 years old
- Presence of cleft palate
- Without congenital mandibular hypoplasia;Control Population 2:
- Age below 3 months
- Presence of an immature breathing pattern, but otherwise healthy

Exclusion Criteria

Control Population 2:
- Congenital malformation.
- Underlying condition that is not known to influence growth.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Outcomes of physical examination:<br /><br>- Length in centimetres.<br /><br>- Head circumference in millimetres.<br /><br>- Weight in kilograms.<br /><br><br /><br>Outcomes of polysomnography:<br /><br>- Apnea Hypopnea Index (AHI).<br /><br>- Oxygen Desaturation Index (ODI).<br /><br><br /><br>Outcomes of ENT exam and nasoendoscopy:<br /><br>- Malampatti score.<br /><br>- Cormack-Lehane score.<br /><br>- Sher-classification.<br /><br><br /><br>Outcomes of measurements on CT-scans:<br /><br>- Distances in millimetres.</p><br>

Secondary Outcome Measures