An integrated neuromuscular training intervention applied in primary schools induces epigenetic modifications in disease-related genes
Not Applicable
- Conditions
- The study population is apparently healthy school-aged children.Not Applicable
- Registration Number
- ISRCTN16744821
- Lead Sponsor
- University of Girona
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Ongoing
- Sex
- All
- Target Recruitment
- 68
Inclusion Criteria
- No evidence of chronic or acute illness in the month preceding potential enrollment2. Age between 7 and 9 years
Exclusion Criteria
- Major congenital abnormalities2. Illness or chronic use of medication3. Musculoskeletal, neurological disorder and/or a medication therapy that could alter postural stability and cardiorespiratory function4. Attending fewer than 80 % of the physical education classes
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method DNA methylation is assessed with the Illumina 900K microarray at baseline, after a 3 month integrated neuromuscular training intervention and will be assessed after a 10 month integrated neuromuscular training intervention
- Secondary Outcome Measures
Name Time Method Physical fitness and fundamental motor skills are assessed through validated and standardized testing batteries:1. Endurance – assessed with 800 m run test before and after the intervention2. Speed and agility – assessed with Shuttle run 10 x 5 m test before and after the intervention3. Explosive power of legs - assessed with the standing long jump test before and after the intervention4. Handgrip strength – assessed with an analog hand dynamometer (TKK 5001, Grip-A, Takei, Tokyo, Japan) before and after the intervention5. Flexibility – assessed with the sit-and-reach test before and after the intervention6. Balance – assessed with the closed eyes bipedal test performed on a Wii balance board platform before and after the intervention7. Fundamental motor skills (locomotor, control and manipulative) – assessed with the CAMSA test before and after the intervention