ISRCTN16744821
Active, not recruiting
未知
An integrated neuromuscular training intervention applied in primary schools induces epigenetic modifications in disease-related genes: A genome-wide DNA methylation study
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- The study population is apparently healthy school-aged children.
- Sponsor
- University of Girona
- Enrollment
- 68
- Primary Endpoint
- DNA methylation is assessed with the Illumina 900K microarray at baseline, after a 3 month integrated neuromuscular training intervention and will be assessed after a 10 month integrated neuromuscular training intervention
- Status
- Active, not recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •No evidence of chronic or acute illness in the month preceding potential enrollment
- •Age between 7 and 9 years
Exclusion Criteria
- •Major congenital abnormalities
- •Illness or chronic use of medication
- •Musculoskeletal, neurological disorder and/or a medication therapy that could alter postural stability and cardiorespiratory function
- •Attending fewer than 80 % of the physical education classes
Outcomes
Primary Outcomes
DNA methylation is assessed with the Illumina 900K microarray at baseline, after a 3 month integrated neuromuscular training intervention and will be assessed after a 10 month integrated neuromuscular training intervention
Secondary Outcomes
- Physical fitness and fundamental motor skills are assessed through validated and standardized testing batteries:1. Endurance – assessed with 800 m run test before and after the intervention2. Speed and agility – assessed with Shuttle run 10 x 5 m test before and after the intervention3. Explosive power of legs - assessed with the standing long jump test before and after the intervention4. Handgrip strength – assessed with an analog hand dynamometer (TKK 5001, Grip-A, Takei, Tokyo, Japan) before and after the intervention5. Flexibility – assessed with the sit-and-reach test before and after the intervention6. Balance – assessed with the closed eyes bipedal test performed on a Wii balance board platform before and after the intervention7. Fundamental motor skills (locomotor, control and manipulative) – assessed with the CAMSA test before and after the intervention
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