ISRCTN16744821进行中（未招募）Unknown
An integrated neuromuscular training intervention applied in primary schools induces epigenetic modifications in disease-related genes: A genome-wide DNA methylation study
适应症
试验速览
- 阶段
- Unknown
- 状态
- 进行中（未招募）
- 入组人数
- 68
- 主要终点
- DNA methylation is assessed with the Illumina 900K microarray at baseline, after a 3 month integrated neuromuscular training intervention and will be assessed after a 10 month integrated neuromuscular training intervention
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •No evidence of chronic or acute illness in the month preceding potential enrollment
- •Age between 7 and 9 years
排除标准
- •Major congenital abnormalities
- •Illness or chronic use of medication
- •Musculoskeletal, neurological disorder and/or a medication therapy that could alter postural stability and cardiorespiratory function
- •Attending fewer than 80 % of the physical education classes
结局指标
主要结局
DNA methylation is assessed with the Illumina 900K microarray at baseline, after a 3 month integrated neuromuscular training intervention and will be assessed after a 10 month integrated neuromuscular training intervention
次要结局
- Physical fitness and fundamental motor skills are assessed through validated and standardized testing batteries:1. Endurance – assessed with 800 m run test before and after the intervention2. Speed and agility – assessed with Shuttle run 10 x 5 m test before and after the intervention3. Explosive power of legs - assessed with the standing long jump test before and after the intervention4. Handgrip strength – assessed with an analog hand dynamometer (TKK 5001, Grip-A, Takei, Tokyo, Japan) before and after the intervention5. Flexibility – assessed with the sit-and-reach test before and after the intervention6. Balance – assessed with the closed eyes bipedal test performed on a Wii balance board platform before and after the intervention7. Fundamental motor skills (locomotor, control and manipulative) – assessed with the CAMSA test before and after the intervention
研究者
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