Analysis of Plasminogen Activator Inhibitor-1 Level in Chronic Serous Chorioretinopathy and Polypoidal Choroidal Vasculopathy
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Serum Fibrinogen in active PCV and CSC patients
研究概览
简要总结
Thrombotic biomarkers and angiographic characteristics were compared among the de novo patients of central serous chorioretinopathy (CSC), polypoidal choroidal vasculopathy (PCV) and the control.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •neurosensory detachment in optical coherence tomography (OCT)
- •focal leakage in fluorescein angiography (FAG) and/or late choroidal hyperpermeability in indocyanine green angiography (ICGA)
- •subretinal and/or sub-retinal pigment epithelial fluid in OCT
- •branching vascular network and/or polyps in ICGA
- •epiretinal membrane (ERM)
- •without underlying systemic, ophthalmic disease other than ERM
排除标准
- •Previous history of using steroid (oral, topical)
- •Previous history of CSC/PCV
- •Previous history or evidence of intraocular inflammation including uveitis
- •Co-existing retinal or choroidal diseases
- •History of allergic reaction to fluorescein or indocyanine green dye
- •Underlying systemic conditions that could affect the thrombotic profiles (e.g. diabetes, hypertension, metabolic syndrome, coronary artery disease, cerebrovascular diseases, stroke, chronic renal failure, current smoker, pregnancy, sleep disorder)
结局指标
主要结局
Serum Fibrinogen in active PCV and CSC patients
时间窗: Less than 1 week after initial diagnosis
Serum Fibrinogen (mg/dl)
Serum PAI-1 SNP genotyping in active PCV and CSC patients
时间窗: Less than 1 week after initial diagnosis
Serum PAI-1 SNP(single nucleotide polymorphism) genotyping
Serum Factor VIII activity in active PCV and CSC patients
时间窗: Less than 1 week after initial diagnosis
Serum Factor VIII activity (%)
Serum Plasminogen activity in active PCV and CSC patients
时间窗: Less than 1 week after initial diagnosis
Serum Plasminogen activity (%)
Serum D-dimer in active PCV and CSC patients
时间窗: Less than 1 week after initial diagnosis
Serum D-dimer (μg/mL(FEU))
Serum Fibrin degradation product in active PCV and CSC patients
时间窗: Less than 1 week after initial diagnosis
Serum Fibrin degradation product (μg/mL)
Serum PAI-1 antigen in active PCV and CSC patients
时间窗: Less than 1 week after initial diagnosis
Serum PAI-1 (plasminogen activator inhibitor-1) antigen (ng/mL)
次要结局
- Characteristics of indocyanine green angiography in active PCV and CSC patients(Less than 1 week after initial diagnosis)
- Characteristics of fluorescein angiography in active PCV and CSC patients(Less than 1 week after initial diagnosis)