跳至主要内容
临床试验/NCT03476694
NCT03476694Unknown4 期

Effects of Various Volume of Local Anaesthetic Use for Ultrasound Guided Supraclavicular Brachial Plexus Block on Successful Blockade and Diaphragmatic Motility.

B.P. Koirala Institute of Health Sciences2 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2018年7月1日最近更新:
适应症
干预措施

试验速览

阶段
4 期
入组人数
60
试验地点
2
主要终点
hemidiaphragmatic paralysis

研究概览

简要总结

Brachial plexus block as done by landmark technique use large volume of local anaesthetics (at least 30-40 ml), leading to higher incidence of phrenic nerve involvement and diaphragmatic dysfunction. With use of ultrasound dose of local anaesthetic can be reduced. Volume as low as 20 ml when use by ultrasound guidance has shown to provide successful block with no hemidiaphragmatic palsy when compared with nerve stimulation technique. But no study has compared the different volumes of drug on success rate and diaphragmatic motility.So in this study , the investigators want to compare the incidence of hemidiaphragm paralysis and success of block with different volumes of local anaesthetic , so that the lowest effective dose with higher safety profile can be determined.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Double (Participant, Investigator)

入排标准

年龄范围
18 Years 至 60 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • 未提供

排除标准

  • 未提供

研究组 & 干预措施

20ml of 0.75% Ropivacine

Experimental

干预措施: ultra sound guided supraclavicular brachial plexus block (Procedure)

25ml of 0.75% Ropivacine

Experimental

干预措施: ultra sound guided supraclavicular brachial plexus block (Procedure)

结局指标

主要结局

hemidiaphragmatic paralysis

时间窗: within 30 minutes after sucessfull blocade

grading of hemidiaphragmatic paralysis as, complete ,partial and no hemidiaphragmatic paralysis as reduction of diaphragmatic excursion greater than 75%, 25-75%, less than 25% respectively after sucessful blocade.

次要结局

  • sucessful blocade(within 30 minutes of block)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Shambhu Adhikari

Resident doctor

B.P. Koirala Institute of Health Sciences

研究点 (2)

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