Leukemia Inhibitory Factor Level in Intrauterine Growth Restriction Neonates
- Conditions
- to Compare LIF Level in Cord Blood of Embryo's That Are IUGR to Those That Are AGA
- Interventions
- Other: blood sample and tissue sample
- Registration Number
- NCT02518126
- Lead Sponsor
- Rambam Health Care Campus
- Brief Summary
To see if there is a relationship between the level of LIF in IUGR fetuses and compared to the level of LIF in AGA fetuses
- Detailed Description
During embryonic development, there are several cytokines such as: LIF (Leukemia inhibitory factor), ciliary neurotrophic factor (CNTF), epidermal growth factor family (EGF), neuregulin 1 (NRG1) and transforming growth factor β (TGFβ) that were found are associated with neurogenesis and differentiation of brain cells .
LIF is a cytokine that is essential for the development of the central nervous system, and has recently been shown in rats that maternal LIF stimulates placental ACTH that in turn promotes secretion of fetal LIF from nRBC , which in turn promotes brain development of the fetus Other studies on IUGR (Intra Uterine Growth Restriction) have shown that IUGR fetuses have more CP (Cerebral palsy) than those who were AGA (Average for Gestational Age) The hypothesis is that LIF is related to the proper development of the nervous system in the fetus and by testing cord blood of embryos IUGR and the placenta we will find changes in LIF and ACTH compared with AGA fetuses level.
Studies have also shown a relationship between CP and IUGR, but the mechanism for this relationship is unclear.
The purpose of our research is to see if there is a relationship between the level of LIF in IUGR fetuses and compared to the level of LIF in AGA fetuses, in one of two ways:
* Changes in the secretion of ACTH in placenta
* Changes in levels of LIF in the umbilical cord blood
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 40
- Women that the Fetal weight estimate puts the fetus bellow the 10th percentile and those that the fetal weight estimate are between 20th and 80th percentiles
- Women who do not agree
- known Genetic diseases of abnormalities in the fetus
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description control blood sample and tissue sample Women with IUGR embryos so that their fetal weight estimate puts them in a percentile bellow 10th percentile IUGR blood sample and tissue sample Women with AGA embryos so that their fetal weight estimate puts them in a percentile between 20th and 80th percentiles
- Primary Outcome Measures
Name Time Method LIF Protein Level in IUGR Neonates vs. AGA neonates 2 years
- Secondary Outcome Measures
Name Time Method