The Effect of Periradial Injection of Papaverine Versus Nitroglycerine on Radial Artery Diameter Prior to Cannulation.
Trial Snapshot
- Phase
- Early Phase 1
- Status
- Completed
- Sponsor
- Enrollment
- 90
- Locations
- 1
- Primary Endpoint
- diameter of radial artery
Study Overview
Brief Summary
Compare the effect of periradial injection of papaverine versus nitroglycerine on radial artery diamter before cannulation of it in cardiac surgery.
Detailed Description
we want in this study to facilitate radial artery canulation and decrease the number of attemps of puncture which may lead to disappearance of the pulse.
The aim of this study is to compare the effect of adding papaverine to local anesthetic xylocaine versus adding nitroglycerine to it on the diameter and palpability of radial artery and if perioperative spasm will decrease significantly with one of these methods.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 20 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients who will be included in the study are those scheduled for elective cardiac surgery who are hemodynamically stable.
Exclusion Criteria
- •Any patient with negative modified Allen test, atrioventricular block, glaucoma, altered liver function, unstable hemodynamics, emergency surgeries, and peripheral vascular disease.
Arms & Interventions
papaverine
Intervention: papaverine (Drug)
nitroglycerine
Intervention: nitroglycerine (Drug)
xlyocaine
Intervention: xlyocaine (Drug)
Outcomes
Primary Outcomes
diameter of radial artery
Time Frame: 20 minutes
after periradial injection of one of the drugs we will feel the radial artery pulse and record if there is a change in the palpatory score and mesure the diameter of the radial artery by ultrasound in cardiac surgery patients
Secondary Outcomes
- spasm of radial artery(24 hours)
Investigators
ahmed said
lecture of anesthesia
Kasr El Aini Hospital