Various types of meropenem administration in patients with VAP snd ARC
Phase 3
Recruiting
- Conditions
- ventilator associated pneumonia.Ventilator associated pneumoniaJ95.851
- Registration Number
- IRCT20130917014693N12
- Lead Sponsor
- Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Definitive or probable diagnosis of VAP based upon CPIS
Patients with high probability for ARC according to ARC scoring systems. (score>7)
Patients receiving meropenem
Patient`s serum creatinine level less than 1.3 mg/dL
Patients >18 years old
Exclusion Criteria
Patients sensitive to meropenem
Infection due to gram-positive bacteria
Patients diagnosed with acute kidney injury
Patients non-responsive to meropenem during the first 7 days of treatment and therefore needing medication change
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Ft>MIC in at least 50% of dose time interval. Timepoint: days 2,3,5 during meropenem administration. Method of measurement: measuring meropenem plasma concentration by HPLC.
- Secondary Outcome Measures
Name Time Method Improvement in clinical factors. Timepoint: daily. Method of measurement: observation.