effects of propolis in pneumonia
- Conditions
- Severe pneumonia.Sepsis due to Streptococcus pneumoniaeA40.3
- Registration Number
- IRCT20220902055856N1
- Lead Sponsor
- Oroumia University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 42
the patient must be at least 18 years old and should be diagnosed with pneumonia which requires medicinal intervention
pneumonia symptoms including: cough which has just started or gotten worst, purulent sputum, witnessing pneumonia-related symptoms in the chest examination, dyspnea (a breathing rate more than 20 per minute) or tachycardia, or mechanical ventilation should be seen in the first 72 hours
2 or more of the SIRS symptoms in the last 24 hours including: a body temperature below 36 or above 38, heartbeat above 90 per minute, Breathing rate above 20 per minute, or a CO2 blood concentration above 4.2 KPa, WBC>12000/mm3, OR<4000.mm3, OR>10%
ashtma
allergies
known rheumatological diseases
acute heart failure
malignancies
cystic fibrosis and chronic kidney failure with a GFR below 30 ml/min
hepatic failure with a C child score
a history of allergy to propolis
usage of any other antioxidants
patients with a transplanted organ
patients receiving immunosuppressive drugs
pregnancy or lactation
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Measuring the ESR parameter (erythrocyte sedimentation rate). Timepoint: At the beginning of the study and also 7 days after the start of the intervention. Method of measurement: ESR: will be measured by observing.;CRP (C reactive protein) levels. Timepoint: At the beginning of the study and also 7 days after the start of the intervention. Method of measurement: CRP: will be measured with special kits.
- Secondary Outcome Measures
Name Time Method Measuring MDA levels (malondialdehyde). Timepoint: At the beginning of the study and also 7 days after the start of the intervention. Method of measurement: by MDA kits purchased from Padgine Teb Co.;Measuring TAC levels (Total antioxidant capacity). Timepoint: At the beginning of the study and also 7 days after the start of the intervention. Method of measurement: by TCA kits purchased from Padgine Teb Co.;WBC changes (White blood cells). Timepoint: At the beginning of the study and also 7 days after the start of the intervention. Method of measurement: by cell counter device.;Reducing the length of hospitalization. Timepoint: From admission to discharge. Method of measurement: Based on the date of admission and discharge recorded in the patient's file.