MedPath

effects of propolis in pneumonia

Phase 3
Recruiting
Conditions
Severe pneumonia.
Sepsis due to Streptococcus pneumoniae
A40.3
Registration Number
IRCT20220902055856N1
Lead Sponsor
Oroumia University of Medical Sciences
Brief Summary

Not available

Detailed Description

Not available

Recruitment & Eligibility

Status
Recruiting
Sex
All
Target Recruitment
42
Inclusion Criteria

the patient must be at least 18 years old and should be diagnosed with pneumonia which requires medicinal intervention
pneumonia symptoms including: cough which has just started or gotten worst, purulent sputum, witnessing pneumonia-related symptoms in the chest examination, dyspnea (a breathing rate more than 20 per minute) or tachycardia, or mechanical ventilation should be seen in the first 72 hours
2 or more of the SIRS symptoms in the last 24 hours including: a body temperature below 36 or above 38, heartbeat above 90 per minute, Breathing rate above 20 per minute, or a CO2 blood concentration above 4.2 KPa, WBC>12000/mm3, OR<4000.mm3, OR>10%

Exclusion Criteria

ashtma
allergies
known rheumatological diseases
acute heart failure
malignancies
cystic fibrosis and chronic kidney failure with a GFR below 30 ml/min
hepatic failure with a C child score
a history of allergy to propolis
usage of any other antioxidants
patients with a transplanted organ
patients receiving immunosuppressive drugs
pregnancy or lactation

Study & Design

Study Type
interventional
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Measuring the ESR parameter (erythrocyte sedimentation rate). Timepoint: At the beginning of the study and also 7 days after the start of the intervention. Method of measurement: ESR: will be measured by observing.;CRP (C reactive protein) levels. Timepoint: At the beginning of the study and also 7 days after the start of the intervention. Method of measurement: CRP: will be measured with special kits.
Secondary Outcome Measures
NameTimeMethod
Measuring MDA levels (malondialdehyde). Timepoint: At the beginning of the study and also 7 days after the start of the intervention. Method of measurement: by MDA kits purchased from Padgine Teb Co.;Measuring TAC levels (Total antioxidant capacity). Timepoint: At the beginning of the study and also 7 days after the start of the intervention. Method of measurement: by TCA kits purchased from Padgine Teb Co.;WBC changes (White blood cells). Timepoint: At the beginning of the study and also 7 days after the start of the intervention. Method of measurement: by cell counter device.;Reducing the length of hospitalization. Timepoint: From admission to discharge. Method of measurement: Based on the date of admission and discharge recorded in the patient's file.
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