Arterial Calcifications in Nocturnal Hemodialysis and Renal Transplantation Versus Conventional Dialysis
- Conditions
- Kidney Disease
- Registration Number
- NCT00950573
- Lead Sponsor
- Dianet Dialysis Centers
- Brief Summary
Objective:
1. To assess whether nocturnal hemodialysis and renal transplantation are associated with less progression of coronary arterial calcification, compared with conventional hemodialysis and peritoneal dialysis;
2. To identify the risk factors for coronary arterial calcification in dialysis and transplant patients, and to assess a possible interaction with treatment modality.
- Detailed Description
To assess whether nocturnal hemodialysis and renal transplantation are associated with less progression of coronary arterial calcification, compared with conventional hemodialysis and peritoneal dialysis; To identify the risk factors for coronary arterial calcification in dialysis and transplant patients, and to assess a possible interaction with treatment modality.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 184
- ESRD
- current age > 18 and < 75 yr
- ability to understand the study procedures
- willingness to provide written informed consent
- life expectancy < 3 months
- claustrophobia
- allergy to iodinated contrast
- treatment incompliance, i.e. non-adherence to dialysis regimens and drug use
- GFR < 30 ml/min (according to MDRD formula) in renal transplant patients
- pregnancy
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in coronary artery calcification score 3 yrs The coronary artery calcification score is measured in Agatston units or cubic millimeters and ranges from zero to theoretically infite. This coronary artery calcicifcation score is a total score for all coronary arteries. A higher score, and thus a higher increase in coronary artery calcification score, therefore represents a worse outcome.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
Dianet Dialysis Centers
🇳🇱Utrecht, Netherlands
University Medical Center Utrecht
🇳🇱Utrecht, Netherlands
Dianet Dialysis Centers🇳🇱Utrecht, Netherlands