Respiratory responses to exercise in older and younger adults

Not Applicable

• Conditions: Respiratory ageing; Respiratory - Normal development and function of the respiratory system

• Registration Number: ACTRN12619000461190
• Lead Sponsor: niversity of Southern Queensland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-03-20
• Study Completion: 2020-10-27
• Last Update Posted: 7 March 2022

Recruitment & Eligibility

• Status: Stopped early
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

18-35 years or 65-84 years of age.

Exclusion Criteria

1.Aged under 18 years; 36 to 64 years; or over 84 years
2.Epilepsy
3.Diabetes
4.Cardiac conditions
5.Respiratory conditions
6.Coagulation abnormalities
7.Oesophageal varices or strictures
8.Dysphagia (difficulty swallowing)
9.Reactions to medical adhesives
10.Restrictive equipment inhibiting effective breathing
11.Implanted medical device/s or cardiac pacemaker
12.Medical condition or surgical procedure involving the nose, throat, diaphragm, lungs or stomach
13.Stroke
14.Recent banding of oesophageal strictures
15.Surgical procedures affecting the nose, throat, stomach, diaphragm or lungs
16.History of head, facial or airway trauma
17.Currently pregnant or having given birth in the previous 12 months
18.Blood thinners, anticoagulants or fish oils
19.Known reactions to medications
20.Currently taking medication

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Transdiaphragmatic pressure. Transdiaphragmatic pressure is measured using an oesophageal catheter integrated with two pressure transducers (one oesophageal and one gastric).[Visit 3<br>Before exercise induced by cervical magnetic stimulation (CMS)<br>During exercise (dynamic measurements)<br>Immediately post exercise by CMS<br>15 minutes post exercise by CMS<br>30 minutes post exercise by CMS];Abdominal pressure. Measured using an oesophageal catheter integrated with two pressure transducers (one oesophageal and one gastric).[Visit 3<br>Before exercise induced by abdominal magnetic stimulation (AMS)<br>During exercise (dynamic measurements)<br>Immediately post exercise by AMS<br>15 minutes post exercise by AMS<br>30 minutes post exercise by AMS];VO2 Maximum. Assessed using a Vyntus™ CPX Metabolic Cart.[Visit 2 and 3<br>Evaluated during exercise]