Comparing Sensory Nerve Conduction and Quantitative Sensory Testing Thresholds Between Matched Patients With Nonspecific Low Back Pain Categorized as Responders or Non-Responders to Exercise Therapy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Chronic Low-back Pain
- Sponsor
- Ahram Canadian University
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Sural Sensory Nerve Conduction Amplitude
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
This observational study aims to compare measures of sensory nerve function between chronic low back pain patients matched for baseline pain and disability levels who are then classified as responders or non-responders after completing a 12-week tailored exercise program. Measures collected include sural sensory nerve conduction, quantitative sensory testing for pressure and heat pain thresholds, and psychosocial questionnaires. It is hypothesized that baseline sensory nerve dysfunction may be associated with reduced response to exercise therapy in chronic low back pain.
Detailed Description
While exercise is commonly prescribed for chronic nonspecific low back pain (NSLBP), patient responses are variable. Differences in baseline sensory nerve function could plausibly contribute to exercise therapy outcomes. This cross-sectional quantitative observational study will investigate if baseline sensory nerve conduction amplitudes and quantitative sensory testing (QST) pain thresholds differ between matched NSLBP patients later categorized as responders or non-responders to a 12-week standardized exercise regime. A sample of 50 NSLBP participants with matched baseline pain and disability will undergo a tailored 12-week exercise intervention and 6-month follow-up. Blinded assessors will perform post-intervention sensory nerve conduction and QST measures. It is hypothesized that exercise therapy responders will show greater improvements in sensory thresholds correlating with pain relief. Results aim to elucidate neural factors associated with long-term exercise therapy outcomes in chronic low back pain.
Investigators
Mohamed Magdy ElMeligie
Lecturer of Physical Therapy and Director of Electromyography Lab
Ahram Canadian University
Eligibility Criteria
Inclusion Criteria
- •Adults ages 20-60 years
- •Nonspecific chronic low back pain \>3 months
- •Baseline pain ≥6/10 and disability ≥40%
Exclusion Criteria
- •Radicular leg pain
- •Prior lumbar surgery
- •Serious spinal pathology
Outcomes
Primary Outcomes
Sural Sensory Nerve Conduction Amplitude
Time Frame: Baseline
Baseline antidromic sural sensory nerve action potential amplitude (measured in microvolts) assessed through nerve conduction study.
Secondary Outcomes
- Pressure Pain Threshold(Baseline)
- Heat Pain Threshold(Baseline)
- Superficial Peroneal Sensory Nerve Conduction Amplitude(Baseline)