NCT01361620已完成不适用
Genotypic and Phenotypic Correlates of Resistance to Anti-platelet Actions of Aspirin in an At-risk Patient Population and in the General Population
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 190
- 试验地点
- 1
- 主要终点
- Whole Blood Coagulation
研究概览
简要总结
The study seeks to identify genomic markers associated with aspirin resistance.
详细描述
Not desired
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Volunteers 40 to 80 years old willing to sign consent and take 81 mg of aspirin for 7 - 10 days and return for laboratory testing.
排除标准
- •Patient requiring more than 81 mg aspirin daily
- •Known GI bleeding attributed to ASA
- •Active peptic ulcer disease or history within the last year
- •Known aspirin allergy
- •Current use of:
- •warfarin,
- •NSAIDs (except aspirin),
- •clopidogrel,
- •dipyridamole,
- •fish-oil/omega 3 supplements,
- •Women of childbearing potential who are pregnant, planning to become pregnant or nursing.
研究组 & 干预措施
Aspirin
Other
All subjects took 7-10 days of 81 mg aspirin
干预措施: aspirin (Drug)
结局指标
主要结局
Whole Blood Coagulation
时间窗: Single measurement at 7-10 days after beginning aspirin
Whole blood coagulation after stimulation with arachidonic acid, as measured in the VerifyNow Aspirin system (Accumetrics). Aspirin response units (ARU) are the residual coagulation present in patients taking aspirin. The higher the ARU, the greater residual coagulation (resistance) to the aspirin effect.
次要结局
未报告次要终点
研究者
研究点 (1)
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