ISRCTN64082539
Completed
Not Applicable
Antiplatelet Regimen Tailoring after primary Percutaneous Coronary Intervention (ART-PCI): a single centre longitudinal cohort prospective trial
Clinical Centre of Serbia (Serbia)0 sites1,700 target enrollmentFebruary 18, 2010
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- ST-elevation myocardial infarction (STEMI)
- Sponsor
- Clinical Centre of Serbia (Serbia)
- Enrollment
- 1700
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. ST\-elevation myocardial infection (STEMI) patients undergoing primary PCI in our institution
- •2\. Both genders, aged greater than 18 years
- •3\. Platelet residual aggregation (PRA) assessed 24 hours after the loading with clopidogrel 600 mg
- •4\. Control group: 1000 patients enrolled in the RISK\-PCI trial (see http://www.controlled\-trials.com/ISRCTN83474650\) in our centre from February 1st, 2006 till June 1st, 2008, who did not have platelet function assays
- •Low responders to clopidogrel will be subjected to ART if there is no exclusion criteria for ART.
Exclusion Criteria
- •1\. Not alive until 24 hours from clopidogrel loading 600 mg
- •2\. Aged greater than 75 years
- •3\. Percutaneous balloon angioplasty (POBA) without stenting
- •4\. Failed pPCI
- •5\. Active bleeding in hospital
- •6\. Coronary dissection with pericardial collection
- •7\. Haemoglobin (Hb) less than 80 g/dL needing transfusion in hospital
- •8\. Simultaneous treatment with oral anticoagulants
- •9\. Candidates for urgent bypass surgery
- •10\. Low basal thrombin receptor activating peptide (TRAP) value (less than 500 AU/minute)
Outcomes
Primary Outcomes
Not specified
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