Clinical Application of Low-Field Magnetic Resonance Imaging in Patients on Extracorporeal Cardiopulmonary Resuscitation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- Feasibility of 0.23-T MRI examination
研究概览
简要总结
Timely identification of acute brain injury (ABI) patterns in patients with extracorporeal cardiopulmonary resuscitation (ECPR) is essential for prognostic assessment and optimization of clinical management, particularly anticoagulation strategies. This study aimed to evaluate the safety and feasibility of early 0.23-T MRI examination in ECPR patients. The investigators further assessed the image quality of the 0.23-T MRI and investigated the incidence and patterns of ABI, as well as their associations with neurological outcomes. This prospective observational study was conducted in the emergency intensive care unit (EICU) of Beijing Chaoyang Hospital, a high-volume ECPR center. The primary outcome was the feasibility of performing 0.23-T MRI in patients undergoing ECPR, defined as successful completion of the examination without serious adverse events (AEs).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Enrolled patients were those with out-of-hospital cardiac arrest of presumed cardiac cause, supported by ECPR, who achieved ROSC but remained unconscious and unable to obey verbal commands.
排除标准
- •age < 18 years
- •unwitnessed cardiac arrest
- •pregnancy
- •contraindications to MRI (except ECPR, for which safety with 0.23-T MRI has been proved)
- •physical dimensions exceeding scanner limits
- •refusal of consent by the family
研究组 & 干预措施
Enrolled patients were those with out-of-hospital cardiac arrest of presumed cardiac cause
结局指标
主要结局
Feasibility of 0.23-T MRI examination
时间窗: From the initiation of the MRI scan until 6 hours after its completion.
Defined as the percentage of participants who successfully complete the MRI examination without experiencing serious adverse events (AEs). AEs include a decrease in ECMO flow \> 10%, a change in mean arterial pressure of ± 20%, or a change in minute ventilation \> 20%.
次要结局
- Image Quality(Within 6 hours after the completion of the MRI scan.)
- Incidence of Acute Brain Injury (ABI)(From the onset of cardiac arrest to the completion of the MRI scan)
- The association between ABI and neurological outcomes(3 months after ROSC.)
研究者
Tang Ziren
professor
Capital Medical University