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Clinical Trials/CTRI/2024/12/078464
CTRI/2024/12/078464Not yet recruitingNot Applicable

Study of the Clinical Profile and Liver Function Abnormalities in Heart Failure

D Y Patil Hospital and School Of Medicine1 site in 1 country230 target enrollmentStarted: December 31, 2024Last updated:

Trial Snapshot

Phase
Not Applicable
Status
Not yet recruiting
Sponsor
Enrollment
230
Locations
1
Primary Endpoint
1)To analyze the clinical profile in patients with heart failure

Study Overview

Brief Summary

Heart failure (HF) is characterized by the inability of systemic perfusion to meet the body’s

metabolic demands and is usually caused by cardiac pump dysfunction and may

occasionally present with symptoms of a non cardiac disorder such as hepatic

dysfunction. A spectrum of hepatic derangement occur in HF particularly in the setting of

right heart failure (RHF). Passive hepatic congestion due to increased central venous

pressure may cause elevations of liver enzymes and both direct and indirect serum

bilirubin.Heart failure can severely decrease the functional capacity of a patient and

increase mortality risk. It is imperative to diagnose and effectively treat the disease to

prevent recurrent hospitalizations, improve quality of life, and enhance patient outcomes.

Present study was undertaken, mainly to emphasize the importance of early identification

of liver serum biochemical markers in heart failure patients. Early and adequate treatment

of the underlying cause of heart failure reverts liver function derangement to normal and

prevents permanent liver damage.

Study Design

Study Type
Observational

Eligibility Criteria

Ages
18.00 Year(s) to 80.00 Year(s) (—)
Sex
All

Inclusion Criteria

  • 1.Patients with heart failure 2.Above age of 18 years.

Exclusion Criteria

  • 1.History of alcoholism.
  • 2.Past history of jaundice.
  • 3.Recent intake of hepatotoxic and cholestatic drugs.
  • 4.Hepatitis 5.Pregnancy.
  • 6.Blood transfusion.
  • 7.Hemolytic disorders.
  • 8.Chronic liver disease.

Outcomes

Primary Outcomes

1)To analyze the clinical profile in patients with heart failure

Time Frame: Baseline | 1 year

2)To assess the liver function abnormalities in patients with heart failure

Time Frame: Baseline | 1 year

Secondary Outcomes

  • To correlate the changes in liver function abnormalities in relation with the duration of(heart failure.)

Investigators

Sponsor
D Y Patil Hospital and School Of Medicine
Sponsor Class
Private medical college
Responsible Party
Principal Investigator
Principal Investigator

Keyancy Patel

D Y Patil medical college

Study Sites (1)

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