Study of the Clinical Profile and Liver Function Abnormalities in Heart Failure
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 230
- Locations
- 1
- Primary Endpoint
- 1)To analyze the clinical profile in patients with heart failure
Study Overview
Brief Summary
Heart failure (HF) is characterized by the inability of systemic perfusion to meet the body’s
metabolic demands and is usually caused by cardiac pump dysfunction and may
occasionally present with symptoms of a non cardiac disorder such as hepatic
dysfunction. A spectrum of hepatic derangement occur in HF particularly in the setting of
right heart failure (RHF). Passive hepatic congestion due to increased central venous
pressure may cause elevations of liver enzymes and both direct and indirect serum
bilirubin.Heart failure can severely decrease the functional capacity of a patient and
increase mortality risk. It is imperative to diagnose and effectively treat the disease to
prevent recurrent hospitalizations, improve quality of life, and enhance patient outcomes.
Present study was undertaken, mainly to emphasize the importance of early identification
of liver serum biochemical markers in heart failure patients. Early and adequate treatment
of the underlying cause of heart failure reverts liver function derangement to normal and
prevents permanent liver damage.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 18.00 Year(s) to 80.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •1.Patients with heart failure 2.Above age of 18 years.
Exclusion Criteria
- •1.History of alcoholism.
- •2.Past history of jaundice.
- •3.Recent intake of hepatotoxic and cholestatic drugs.
- •4.Hepatitis 5.Pregnancy.
- •6.Blood transfusion.
- •7.Hemolytic disorders.
- •8.Chronic liver disease.
Outcomes
Primary Outcomes
1)To analyze the clinical profile in patients with heart failure
Time Frame: Baseline | 1 year
2)To assess the liver function abnormalities in patients with heart failure
Time Frame: Baseline | 1 year
Secondary Outcomes
- To correlate the changes in liver function abnormalities in relation with the duration of(heart failure.)
Investigators
Keyancy Patel
D Y Patil medical college
