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临床试验/CTRI/2024/12/078464
CTRI/2024/12/078464
尚未招募
不适用

Study of the Clinical Profile and Liver Function Abnormalities in Heart Failure

D Y Patil Hospital and School Of Medicine1 个研究点 分布在 1 个国家目标入组 230 人开始时间: 2024年12月31日最近更新:

概览

阶段
不适用
状态
尚未招募
发起方
D Y Patil Hospital and School Of Medicine
入组人数
230
试验地点
1
主要终点
1)To analyze the clinical profile in patients with heart failure

概览

简要总结

Heart failure (HF) is characterized by the inability of systemic perfusion to meet the body’s

metabolic demands and is usually caused by cardiac pump dysfunction and may

occasionally present with symptoms of a non cardiac disorder such as hepatic

dysfunction. A spectrum of hepatic derangement occur in HF particularly in the setting of

right heart failure (RHF). Passive hepatic congestion due to increased central venous

pressure may cause elevations of liver enzymes and both direct and indirect serum

bilirubin.Heart failure can severely decrease the functional capacity of a patient and

increase mortality risk. It is imperative to diagnose and effectively treat the disease to

prevent recurrent hospitalizations, improve quality of life, and enhance patient outcomes.

Present study was undertaken, mainly to emphasize the importance of early identification

of liver serum biochemical markers in heart failure patients. Early and adequate treatment

of the underlying cause of heart failure reverts liver function derangement to normal and

prevents permanent liver damage.

研究设计

研究类型
Observational

入排标准

年龄范围
18.00 Year(s) 至 80.00 Year(s)(—)
性别
All

入选标准

  • 1.Patients with heart failure 2.Above age of 18 years.

排除标准

  • 1.History of alcoholism.
  • 2.Past history of jaundice.
  • 3.Recent intake of hepatotoxic and cholestatic drugs.
  • 4.Hepatitis 5.Pregnancy.
  • 6.Blood transfusion.
  • 7.Hemolytic disorders.
  • 8.Chronic liver disease.

结局指标

主要结局

1)To analyze the clinical profile in patients with heart failure

时间窗: Baseline | 1 year

2)To assess the liver function abnormalities in patients with heart failure

时间窗: Baseline | 1 year

次要结局

  • To correlate the changes in liver function abnormalities in relation with the duration of(heart failure.)

研究者

发起方
D Y Patil Hospital and School Of Medicine
申办方类型
Private medical college
责任方
Principal Investigator
主要研究者

Keyancy Patel

D Y Patil medical college

研究点 (1)

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