Study of the Clinical Profile and Liver Function Abnormalities in Heart Failure
概览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- D Y Patil Hospital and School Of Medicine
- 入组人数
- 230
- 试验地点
- 1
- 主要终点
- 1)To analyze the clinical profile in patients with heart failure
概览
简要总结
Heart failure (HF) is characterized by the inability of systemic perfusion to meet the body’s
metabolic demands and is usually caused by cardiac pump dysfunction and may
occasionally present with symptoms of a non cardiac disorder such as hepatic
dysfunction. A spectrum of hepatic derangement occur in HF particularly in the setting of
right heart failure (RHF). Passive hepatic congestion due to increased central venous
pressure may cause elevations of liver enzymes and both direct and indirect serum
bilirubin.Heart failure can severely decrease the functional capacity of a patient and
increase mortality risk. It is imperative to diagnose and effectively treat the disease to
prevent recurrent hospitalizations, improve quality of life, and enhance patient outcomes.
Present study was undertaken, mainly to emphasize the importance of early identification
of liver serum biochemical markers in heart failure patients. Early and adequate treatment
of the underlying cause of heart failure reverts liver function derangement to normal and
prevents permanent liver damage.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 80.00 Year(s)(—)
- 性别
- All
入选标准
- •1.Patients with heart failure 2.Above age of 18 years.
排除标准
- •1.History of alcoholism.
- •2.Past history of jaundice.
- •3.Recent intake of hepatotoxic and cholestatic drugs.
- •4.Hepatitis 5.Pregnancy.
- •6.Blood transfusion.
- •7.Hemolytic disorders.
- •8.Chronic liver disease.
结局指标
主要结局
1)To analyze the clinical profile in patients with heart failure
时间窗: Baseline | 1 year
2)To assess the liver function abnormalities in patients with heart failure
时间窗: Baseline | 1 year
次要结局
- To correlate the changes in liver function abnormalities in relation with the duration of(heart failure.)
研究者
Keyancy Patel
D Y Patil medical college