Evaluation of Topical B12 for the Treatment of Childhood Atopic Dermatitis
- Conditions
- Eczema
- Registration Number
- NCT00465699
- Lead Sponsor
- Spartanburg Regional Family Medicine
- Brief Summary
This study is being done to see in B12 applied to the skin will improve the symptoms of eczema in children compared to a placebo creme
- Detailed Description
INTRODUCTION: Atopic dermatitis is a prevalent disease process in children, affecting up to 20% of children in the United States. Various treatment options are available to treat atopic dermatitis to include topical emollients, topical steroids, and topical calcineurin inhibitors. Each treatment option has benefits and potential risks. This study was done to determine if topical B12 could be a tolerable and efficacious alternative treatment option in this population.
METHODS: The study was conducted as a placebo-controlled, double-blind, prospective, randomized clinical trial with intraindividual left ⁄ right comparison. Parents were given 2 containers of creams and instructed to apply the Vitamin B12 cream to one side of the body and the placebo cream to the contralateral side according to the randomization scheme.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 50
- children presenting to the Center for Family Medicine or Regional Pediatrics between the ages of 6 months and 18 years old with atopic dermatitis
- unwillingness of parent to consent to study protocol, pregnancy or lactation, eczema with superinfection present, known history of allergy to Vitamin B12 or components of the base cream, topical treatment with corticosteroids in the 4 weeks prior to enrollment
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Reduction in SCORAD at 2 and 4 weeks
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Center for Family Medicine
🇺🇸Spartanburg, South Carolina, United States