Prehabilitation and Coronary Artery Bypass Grafting

Not Applicable

Completed

• Conditions: Coronary Artery Bypass Graft
• Interventions: Other: Resistant training (Prehabilitation)

• Registration Number: NCT04993976
• Lead Sponsor: Riphah International University

Brief Summary

To evaluate the effects of Prehabilitation Resistance training on frailty and functional capacity in mild to moderate clinically frail patients awaiting Coronary Artery Bypass Grafting) CABG. This study will contribute to describing the effect of resistance training in mild to moderate frails patients and were directed to be the part of cardiac rehabilitation and define the effects of cardiac prehabilitation and to check whether the effects of resistance training or routine training is similar for quality of recovery in mild to moderate frails patients which undergone CABG.

Detailed Description

In literature, Coronary Artery Bypass Graft (CABG) is a form of heart surgery that redirects blood around clogged arteries to increase blood flow and oxygen to the heart. During CABG surgery, the surgeon uses a portion of a healthy vessel (either an artery or vein) from the leg, chest, or arm to create a bypass around the clogged artery. During CABG surgery with cardiopulmonary bypass, a heart-lung machine artificially maintains circulation blood and oxygenation while the surgeon operates on the heart. It includes exercise, lifestyle changes, education, and emotional support. It can help improve patient's health and enable them to live a more active life after the patient has had a heart attack or heart surgery or if the patient has long-term heart problems such as heart failure.

The time spent waiting for cardiac surgery to be scheduled is a period of great uncertainty for a patient. There appears to be heightened anxiety regarding the inclusion of physical activity in this time period, mainly as a result of their current cardiac condition or diagnosis

Study Timeline

• Study Start: 2021-03-01
• Primary Completion: 2021-08-01
• Study Completion: 2021-08-01
• Study First Submitted: 2021-08-05
• Study First Submitted QC: 2021-08-05
• Study First Posted: 2021-08-06
• Status Verified: 2021-12
• Last Update Submitted: 2021-12-13
• Last Update Posted: 2021-12-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 74

Inclusion Criteria

• Patients undergoing elective primary isolated coronary artery bypass grafting,

  • Patients with double and triple-vessel coronary artery disease.
  • Mild to moderately frail patients with a clinical frailty score of 5 -6 at the time of accepting surgery at the outpatient cardiothoracic surgical clinic.

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Exclusion Criteria

• Patient with musculoskeletal disability and neurological disability affecting respiratory rate.

  • Patient with renal dysfunction requiring dialysis, use of immunosuppressive treatments during the 30-day period before surgery,
  • Left ventricular ejection fraction <30%
  • concomitant valve disease
  • Patient having dysrhythmias or pacemaker dependent
  • Those patients who are severely frail (CFS 7-9)

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Prehabilitation group	Resistant training (Prehabilitation)	Strength training along with warm-up and cool down for 8 weeks

Primary Outcome Measures

Name	Time	Method
Frailty	8 weeks	It is a scale ranges from 1 (very fit) to 9 (terminally ill). with common cut-off categories classified as non-frail (scores 1-3), vulnerable/ pre-frail (score 4) and frailty (scores 5-9). it is a simple, quick and highly predictive semi-quantitative tool.

Secondary Outcome Measures

Name	Time	Method
Functional capacity	8 weeks	It is measured through six minute walk test which is a sub-maximal exercise test used to assess aerobic capacity and endurance. The distance covered over a time of 6 minutes is used as the outcome by which to compare changes in performance capacity.

Trial Locations

Locations (1)

Faisalabad Institute of Cardiology.; 🇵🇰 Faisalābad, Punjab, Pakistan