BMS-247550 in Treating Patients With Recurrent or Metastatic Colorectal Cancer
- Registration Number
- NCT00022477
- Lead Sponsor
- University of Chicago
- Brief Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of BMS-247550 in treating patients who have recurrent or metastatic colorectal cancer.
- Detailed Description
OBJECTIVES:
* Determine the objective response rate in patients with locally recurrent or metastatic colorectal cancer treated with BMS-247550.
* Determine the toxicity of this drug in these patients.
* Determine the duration of response, median and overall survival, and time to progression in patients treated with this drug.
OUTLINE: This is a multicenter study.
Patients receive BMS-247550 IV over 3 hours on day 1. Treatment repeats every 21 days in the absence of disease progression or unacceptable toxicity.
Patients are followed every 6 weeks.
PROJECTED ACCRUAL: A total of 21-50 patients will be accrued for this study within 8-10 months.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 24
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description BMS-247550 BMS-247550 IV administration of BMS-247550 once every 21 days
- Primary Outcome Measures
Name Time Method Response rate of BMS-247550 in colon cancer 6 weeks
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (15)
University of Illinois at Chicago
🇺🇸Chicago, Illinois, United States
Louis A. Weiss Memorial Hospital
🇺🇸Chicago, Illinois, United States
University of Chicago Cancer Research Center
🇺🇸Chicago, Illinois, United States
Decatur Memorial Hospital Cancer Care Institute
🇺🇸Decatur, Illinois, United States
Evanston Northwestern Health Care
🇺🇸Evanston, Illinois, United States
Loyola University Medical Center
🇺🇸Maywood, Illinois, United States
Michiana Hematology/Oncology P.C.
🇺🇸South Bend, Indiana, United States
Fort Wayne Medical Oncology and Hematology, Inc.
🇺🇸Fort Wayne, Indiana, United States
Lutheran General Cancer Care Center
🇺🇸Park Ridge, Illinois, United States
LaGrange Memorial Hospital
🇺🇸LaGrange, Illinois, United States
Oncology/Hematology Associates of Central Illinois, P.C.
🇺🇸Peoria, Illinois, United States
Central Illinois Hematology Oncology Center
🇺🇸Springfield, Illinois, United States
Albert Einstein Comprehensive Cancer Center
🇺🇸Bronx, New York, United States
Ingalls Memorial Hospital
🇺🇸Harvey, Illinois, United States
Lakeland Medical Center - St. Joseph
🇺🇸Saint Joseph, Michigan, United States