The Clinical Evaluation of the Laser Interstitial Thermal Therapy (LITT ), Under "Real Time" MRI Guidance, for the "Minimal Invasive" Treatment of Liver Metastasis - a Phase IIa Mono-centric Study, Without Direct Benefice to the Patient
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- BioTex, Inc.
- 入组人数
- 25
- 试验地点
- 2
- 主要终点
- Accuracy of predicted lesion geometry to histologically measured dimensions
研究概览
简要总结
The purpose of this study is to determine if the, MR guided, laser interstitial thermal therapy (LITT) treatment technique can be safety and efficiently used for the human liver metastasis
详细描述
This new "minimally invasive" technique has been tested so far, with success, on animal brain and prostate tumors. LITT has also tested with success by other teams for the treatment of liver metastasis.
The main purpose of this study is to determine if the Visualase, MR guided, laser interstitial thermal therapy device can be safely and efficiently used for the treatment of human liver metastasis originating from the colon and rectal primary tumors.
As secondary objectives for this clinical study is to explore the tolerance of the treatment and its contra indications.
The clinical trial will include a statistical sample of 25 patients and will run over a period of 24 months. The inclusion period will be of 12 months and the patients will be followed up during a period of 7 days after the intervention.
The clinical trial will be performed at the Cochin University Hospital of Paris and the patients will be coming from the oncology / surgery departments of the hospital.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients 18 years of age or older
- •Patients with liver metastasis, originating from colon and liver cancer and proved by histological analysis
- •Patient that are scheduled for a surgical resection of part of the liver,
- •Patient having a liver metastasis, originating from colon and rectal cancer, smaller or equal to 3 cm
- •Patients having the liver metastasis at a distance of at least 1 cm or from the hepatic capsule or/and from a vascular structure
排除标准
- •Patients younger than 18 years old
- •Patients presenting contra indication for MRI studies
- •Patient presenting contra indication to liver surgery
- •Patients who already had other interstitial treatment on the targeted lesion
结局指标
主要结局
Accuracy of predicted lesion geometry to histologically measured dimensions
次要结局
未报告次要终点