Does a Reduction in Renal Function Increase Arterial Stiffness and Left Ventricular Mass? - A Prospective Study of Kidney Donors
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Chronic Kidney Disease
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
- Enrollment
- 124
- Locations
- 1
- Primary Endpoint
- Left ventricular mass as measured by CMR and Echocardiography
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
Studies of patients with established kidney disease, even when this is mild, appear to show that they are at high risk of heart failure, stroke and sudden cardiac death. This may be because kidney disease causes stiffening of the arteries in the body which means that the heart and brain are damaged by high blood pressure. By studying patients before and after the removal of a kidney (uni-nephrectomy) for transplantation the investigators will find out for the first time in man the effect of an isolated reduction in kidney function on the structure and function of the arteries and heart.
Hypotheses. An isolated reduction in GFR occuring after surgical uni-nephrectomy is associated with long term adverse cardiac and vascular effects which include:
- Increased arterial stiffness and left ventricular mass
- Abnormalities in left ventricular systolic and diastolic function
- Increased oxidative stress, inflammation and collagen turnover
Investigators
William E Moody
BHF Clinical Research Fellow
University Hospital Birmingham NHS Foundation Trust
Eligibility Criteria
Inclusion Criteria
- •Potential kidney donor attending University Hospital Birmingham NHS Foundation Trust
- •Current nationally set
Exclusion Criteria
- •Diabetes mellitus
- •Atrial fibrillation
- •Left ventricular dysfunction (ejection fraction \<40% on transthoracic echocardiography)
- •History of cardiovascular or pulmonary disease
- •Evidence of hypertensive end-organ damage.
Outcomes
Primary Outcomes
Left ventricular mass as measured by CMR and Echocardiography
Time Frame: 3 years
Arterial stiffness as measured by pulse wave velocity
Time Frame: 3 years
Secondary Outcomes
- Left ventricular systolic and diastolic elastance measured by echocardiography;(3 years)
- Oxidative stress, inflammation and collagen turnover measured by blood assays of plasma renin, aldosterone, high sensitivity C-reactive protein (hsCRP), procollagen type III aminoterminal peptide (PIIINP) and C-telopeptide for type I collagen (CITP).(3 years)
- Aortic compliance measured by cardiac magnetic resonance imaging(3 years)