Investigating STAT3 as a Driver of Pathology in Periodontitis

Completed

• Conditions: Periodontitis
• Interventions: Other: no intervention

• Registration Number: NCT05506098
• Lead Sponsor: University of Chile

Brief Summary

Periodontitis is a prevalent inflammatory condition that destroys tooth-supporting structures. This condition is associated with pro-inflammatory mediators that utilize STAT3 as an activator of specific genes related to inflammation and tissue destruction. STAT3 has not been studied in the context of periodontitis in humans. We propose that STAT3 is associated with periodontitis. This knowledge might help to further our understanding of periodontitis pathology

Detailed Description

Not available

Study Timeline

• Study Start: 2019-03-20
• Study First Submitted: 2022-08-16
• Study First Submitted QC: 2022-08-16
• Study First Posted: 2022-08-18
• Primary Completion: 2022-10-20
• Study Completion: 2022-10-20
• Status Verified: 2023-01
• Last Update Submitted: 2023-01-26
• Last Update Posted: 2023-01-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

• 18-year-old, in good general health, and had no significant medical history.
• no history of diabetes or other diseases different than periodontitis.

Exclusion Criteria

• Pregnancy and lactation
• Use of antibiotics, immunosuppressive agents, or probiotics within 3 months.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Healthy	no intervention	Subjects without periodontitis
Periodontitis	no intervention	Subjects with periodontitis

Primary Outcome Measures

Name	Time	Method
STAT3 detection in gingival tissues	1 day	Detection of STAT3 in gingival tissues

Trial Locations

Locations (1)

Faculty of Dentistry, University of Chile; 🇨🇱 Santiago, Chile