Is Thymus Size of Infants Who Born to COVID-19 Positive Mothers Associated With Neonatal Morbidities?
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Cardiothymic index
研究概览
简要总结
COVID-19 infected pregnant women is thought to have variable degrees of inflammatory response against the disease. Investigators of present study, suggested that fetuses are affected from the possible fetal inflammatory syndrome in case of maternal COVID-19. Therefore the aim of his study is to evaluate that if the cardiothymic index is affected by the maternal COVID-19 and to demonstrate any possible association of this measurement with neonatal morbidities.
详细描述
COVID-19 infected pregnant women is thought to have variable degrees of inflammatory response against the disease. Fetus is known to be influenced by maternal systemic infections. Thymus size of fetus and the neonate, is proven to be changed by primarily inflammatory/infectious diseases. Investigators of present study, suggested that fetuses are affected from the possible fetal inflammatory syndrome in case of maternal COVID-19. Therefore the aim of his study is to evaluate that if the cardiothymic index is affected by the maternal COVID-19 and to demonstrate any possible association of this measurement with neonatal morbidities.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- — 至 7 Hours（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Infants born to COVID-19 positive or negative mothers
- •Accepted to participate with an informed consent
- •Infants who required to get chest X-ray within the first 6 hours
排除标准
- •Infants whose mothers' have any kind of acute or chronic systemic disease or inflammation/infection
- •Lack of an informed consent
- •Infants who did not require to get chest X-ray within the first 6 hours
研究组 & 干预措施
Infants born to COVID-19 positive mothers
Infants, born to COVID-19 positive mothers, will be evaluated for cardiothymic index in their first chest X-ray.
干预措施: chest x-ray (Diagnostic Test)
Infants born to COVID-19 negative mothers
Infants, born to COVID-19 negative mothers, will be evaluated for cardiothymic index in their first chest X-ray.
结局指标
主要结局
Cardiothymic index
时间窗: 4 months
Cardiothymic index will be measured by using the thymic shadow divided by largest diameter of mediastinum in the chest X-ray of those infants.
次要结局
- Immune profile(6 months)
研究者
Seda Yilmaz Semerci
Neonatologist
Kanuni Sultan Suleyman Training and Research Hospital