Anterior Segment Imaging With Ultrahigh-resolution OCT in Patients With Glaucoma and Pseudoexfoliation Syndrome - a Pilot Study
试验速览
- 阶段
- 不适用
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- 3-dimensional imaging of the anterior eye segment
研究概览
简要总结
The aim of the present study is to develop a measurement protocol for optimal imaging of the anterior segment of the eye, including anterior chamber angle, Schlemm's canal, filtering bleb and pseudoexfoliation deposits on the lens based on measurements in patients with glaucoma and PEX. In glaucoma the structures of the anterior chamber are important for classification, therapy, progression and prognosis and imaging of the angle between the iris and the cornea is the key for open angle and closed angle glaucoma differential diagnosis. For this purpose, a customized ultrahigh resolution Spectral Domain OCT will be used to validate whether the protocol can also be more widely applied in these patients. Based on the obtained measurement protocol, further studies investigating anatomy and pathophysiology of the anterior segment of the eye as well as surgical outcome in patients with glaucoma and PEX can be planned.
The aim of the study is to develop a measurement protocol for OCT imaging and characterization of the anterior chamber in glaucoma patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and women aged over 18 years
- •For patients with primary open angle glaucoma:
- •Diagnosed primary open angle glaucoma
- •Visual field defects and optic nerve head appearance characteristic for glaucoma
- •Open anterior chamber angle as evidenced by gonioscopy
- •No previous glaucoma surgery
- •No previous cataract surgery
- •For patients with primary angle closure:
- •Angle closure predisposition as evidenced from goniosocopy
- •No previous glaucoma surgery
- •For patients with neovascular glaucoma:
- •Neovascularization in the anterior chamber angle
- •For patients with pseudoexfolation deposits on the lens:
- •PEX glaucoma as evidenced from slit lamp examination
- •Visual field defects and optic nerve head appearance characteristic for glaucoma
- •Open anterior chamber angle as evidenced by gonioscopy
- •No previous glaucoma or cataract surgery
- •For glaucoma patients with filtering bleb after trabeculectomy:
- •Patients with history of trabeculectomy secondary to open angle glaucoma in the previous three months
- •No cataract surgery
- •For healthy volunteers:
- •No evidence of ocular disease
- •No degenerative changes in the retina in funduscopy after mydriasis
- •Ametropia less than 3 dpt.
排除标准
- •Presence of any abnormalities preventing reliable measurements as judged by the investigator
- •Pregnancy, planned pregnancy or lactating
- •Ocular inflammation and ocular disease interfering with the study aims as judged by the investigator
研究组 & 干预措施
healthy volunteers
instillation of antiglaucoma treatment in the study eye
干预措施: Pilocarpine (Drug)
结局指标
主要结局
3-dimensional imaging of the anterior eye segment
时间窗: 1 day
次要结局
未报告次要终点
研究者
Gerhard Garhofer
Assoc. Prof. PD Dr.
Medical University of Vienna