Effect of Air Cleaner on the Indoor Allergen Sensitized Allergic Rhinitis Patients

Not Applicable

Completed

Interventions: Device: PuriCare (HEPA Air Cleaner)
Device: Mock device of PuriCare

Brief Summary: This study aimed to assess the impact of air cleanser on allergic rhinitis patients and indoor air quality. Air cleaners will be installed in the bedrooms and living rooms of the mite allergic rhinitis patients who aged 18-60 years.

Main parameters:

- Symptom medication score of allergic rhinitis

Supportive parameters:

* Visual analog scale of allergic rhinitis

* Quality of life score of allergic rhinitis

* Indoor air quality measurement

* Indoor allergen level measurement

Detailed Description: The most important principle in the treatment of allergic diseases is to avoid or reduce exposure to the causative antigen. Causative agents that induce allergic diseases or exacerbate symptoms are classified into indoor and outdoor allergens. House dust mites and pet's hair are typical indoor antigens. Air pollution as well as allergens are important deterioration factors, and environmental management is essential for alleviating symptoms of allergic diseases. Therefore, we are about to evaluate the impact of the air cleaner to the allergic rhinitis patients.

A total of 45 patients will be enrolled in the study and a real air cleaner and a mock-up air cleaner will be randomly installed at ratio of 1: 1 to measure rhinitis symptoms and the changes in indoor air quality after 6 weeks of operation.

Recruitment & Eligibility

Inclusion Criteria

Adults between 19 and 65 years of age
Allergy specialist diagnosis of Moderate to severe persistent allergic rhinitis
Retrospective Rhinoconjunctivitis total symptom score higher than 7
Allergy against house dust mite: Skin prick test, with a more than 3 mm wheal, Serum specific IgE higher than 0.35 kUA/L measured by ImmunoCAP
Who can read and write Korean
Participants those who voluntarily agreed to this study

Exclusion Criteria

Allergy against seasonal allergens (tree, grass, weed pollens)
Patients with rhinitis due to other causes (drug induced rhinitis or infectious rhinitis etc.)
Patients with severe anatomical abnormality that may cause nasal blockage such as nasal septum deviation or nasal polyps
Chronic systemic corticosteroids (≥ 3 months continuous use in past 12 months)
Participants planning to move or change residence within the study period.
Staying away from the home continuously for more than 5 days in the study period.
Having air cleaner previously
Having indoor smoker
If pregnancy test is positive or pregnancy is possible during study period.
Any other reason the participants is deemed unsuitable for participation in clinical trials

Arm && Interventions

Group	Intervention	Description
Aircleaner group	PuriCare (HEPA Air Cleaner)	PuriCare (HEPA Air Cleaner) in active mode
Control comparator	Mock device of PuriCare	Mock device of PuriCare in active mode

Primary Outcome Measures

Name	Time	Method
Daily symptom score of allergic rhinitis	6 weeks	Daily symptom score of allergic rhinitis: * Rhinorrhea * Nasal itchiness * Sneezing * Obstruction
Daily medication score of allergic rhinitis	6 weeks	Daily medication score of allergic rhinitis - Intranasal steroid * Anti-histamine * Leukotriene modifier

Secondary Outcome Measures

Name	Time	Method
Visual analog scale of allergic rhinitis	6 weeks	0 to 10 score of VAS
Quality of life score of allergic rhinitis	6 weeks	questionnaire

Locations (1): Division of Allergy and Immunology Department of Internal Medicine, Yonsei University College of Medicine
🇰🇷
Seoul, Korea, Republic of

Receive instant email notifications about changes in this clinical trial

Receive instant email notifications about changes in this clinical trial